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생쥐에서 사간 추출물의 기억력 감퇴에 대한 개선 효과

Belamcandae Rhizoma Extract Improves Memory Impairment in Mice

생약학회지 2021년 52권 1호 p.55 ~ 60
정지욱,
소속 상세정보
정지욱 ( Jung Ji-Wook ) - Daegu Haany University Division of Biotechnology and Convergence

Abstract


Belamcandae Rhizoma (BR), the rhizome of Belamcanda chinensis (L.) DC., possesses various biological properties such as anti-inflammatory activity, antioxidant activity and antimutagenic activity. However, there have been no studies on the anti-amnesic effect of BR. In this study, we assessed the improvement effect of BR extract on scopolamine-induced amnesia in mice. ICR mice were administrated with BR (50, 100 or 200 mg/kg, p.o.) and were subsequently injected of scopolamine (1 mg/kg, i.p.) 30 min before behavioral tasks (Y-maze, passive avoidance and Morris water maze tasks). To further assess the possible mechanisms of BR, the ex vivo acetylcholinesterase (AChE) activity was also evaluated. BR could ameliorate scopolamine-induced memory impairment and could regulate the cholinergic function by inhibiting the AChE activity. These data demonstrated that BR exert candidate extract against amnesia by restoring the cholinergic activity.

키워드

Belamcanda chinensis; Belamcandae Rhizoma; Scopolamine; Memory; Dementia

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