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Cytotoxic Constituents from the Stem Bark of Chisocheton pentandrus

Natural Product Sciences 2021년 27권 1호 p.18 ~ 27
Retnowati Rurini, Sulistyarti Hermin, Wahidah Nikmatus Zahro, Syarifah Anisa Lailatusy, Salam Suprianto, Nurlelasari, Safari Agus, Harneti Desi, Tanjung Mulyadi, Hidayat Ace Tatang, Maharani Rani, Supratman Unang, Shiono Yoshihito,
소속 상세정보
 ( Retnowati Rurini ) - Universitas Brawijaya Faculty of Mathematics and Natural Sciences Department of Chemistry
 ( Sulistyarti Hermin ) - Universitas Brawijaya Faculty of Mathematics and Natural Sciences Department of Chemistry
 ( Wahidah Nikmatus Zahro ) - Universitas Brawijaya Faculty of Mathematics and Natural Sciences Department of Chemistry
 ( Syarifah Anisa Lailatusy ) - Academy of Pharmacy of Putra Indonesia
 ( Salam Suprianto ) - Universitas Padjadjaran Faculty of Mathematics and Natural Sciences Department of Chemistry
 ( Nurlelasari ) - Universitas Padjadjaran Faculty of Mathematics and Natural Sciences Department of Chemistry
 ( Safari Agus ) - Universitas Padjadjaran Faculty of Mathematics and Natural Sciences Department of Chemistry
 ( Harneti Desi ) - Universitas Padjadjaran Faculty of Mathematics and Natural Sciences Department of Chemistry
 ( Tanjung Mulyadi ) - Universitas Airlangga Faculty of Science and Technology Department of Chemistry
 ( Hidayat Ace Tatang ) - Universitas Padjadjaran Faculty of Mathematics and Natural Sciences Department of Chemistry
 ( Maharani Rani ) - Universitas Padjadjaran Faculty of Mathematics and Natural Sciences Department of Chemistry
 ( Supratman Unang ) - Universitas Padjadjaran Faculty of Mathematics and Natural Sciences Department of Chemistry
 ( Shiono Yoshihito ) - Yamagata University Faculty of Agriculture Department of Food, Life, and Environmental Science

Abstract


Eight cytotoxic constituents, consisting of six triterpenoids, cabralealactone (1), cabraleadiol (2), prototiamin A (3), 23-desmethyllimocin B (5), melianodiol (7) and indicalilacol (8) along with one limonoid, neemfruitins A (4) and one protolimonoid, protoxylocarpin G (6), were isolated from the extract of n-hexane of the stembark of Chisocheton pentandrus. The chemical structures were identified on the basis of spectroscopic evidence and compared to previously reported spectra. These isolated compounds appear for the first time in the plant. Compounds 1 - 8 were evaluated for their cytotoxic effect against MCF-7 breast cancer lines in vitro. Among the isolated compounds, melianodiol (7) showed the strongest cytotoxic activity with IC50 values of 16.8 μM.

키워드

Chisocheton pentandrus; MCF-7 cell lines; Meliaceae; limonoid; triterpenoids

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