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Peroxisome quality control and dysregulated lipid metabolism in neurodegenerative diseases

Experimental & Molecular Medicine 2020년 52권 9호 p.10 ~ 10
Jo Doo-Sin, 박나연, 조동형,
소속 상세정보
 ( Jo Doo-Sin ) - Kyungpook National University Brain Science and Engineering Institute
박나연 ( Park Na-Yeon ) - Kyungpook National University School of Life Sciences
조동형 ( Cho Dong-Hyung ) - Kyungpook National University Brain Science and Engineering Institute

Abstract


In recent decades, the role of the peroxisome in physiology and disease conditions has become increasingly important. Together with the mitochondria and other cellular organelles, peroxisomes support key metabolic platforms for the oxidation of various fatty acids and regulate redox conditions. In addition, peroxisomes contribute to the biosynthesis of essential lipid molecules, such as bile acid, cholesterol, docosahexaenoic acid, and plasmalogen. Therefore, the quality control mechanisms that regulate peroxisome biogenesis and degradation are important for cellular homeostasis. Current evidence indicates that peroxisomal function is often reduced or dysregulated in various human disease conditions, such as neurodegenerative diseases. Here, we review the recent progress that has been made toward understanding the quality control systems that regulate peroxisomes and their pathological implications.

키워드

Neurodegenerative diseases; Pexophagy

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