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Lactobacillus fermentum promotes adipose tissue oxidative phosphorylation to protect against diet-induced obesity

Experimental & Molecular Medicine 2020년 52권 9호 p.12 ~ 12
윤영민, 김기현, Noh Myung-Giun, 박정현, 장몽주, Fang Sung-Soon, 박한수,
소속 상세정보
윤영민 ( Yoon Young-Min ) - Gwangju Institute of Science and Technology Department of Biomedical Science and Engineering
김기현 ( Kim Gi-Hyeon ) - Gwangju Institute of Science and Technology Department of Biomedical Science and Engineering
 ( Noh Myung-Giun ) - Gwangju Institute of Science and Technology Department of Biomedical Science and Engineering
박정현 ( Park Jeong-Hyeon ) - Genome and Company
장몽주 ( Jang Mong-Joo ) - Genome and Company
 ( Fang Sung-Soon ) - Yonsei University College of Medicine Gangnam Severance Hospital Severance Biomedical Science Institute
박한수 ( Park Han-Soo ) - Gwangju Institute of Science and Technology Department of Biomedical Science and Engineering

Abstract


The gut microbiota has pivotal roles in metabolic homeostasis and modulation of the intestinal environment. Notably, the administration of Lactobacillus spp. ameliorates diet-induced obesity in humans and mice. However, the mechanisms through which Lactobacillus spp. control host metabolic homeostasis remain unclear. Accordingly, in this study, we evaluated the physiological roles of Lactobacillus fermentum in controlling metabolic homeostasis in diet-induced obesity. Our results demonstrated that L. fermentum-potentiated oxidative phosphorylation in adipose tissue, resulting in increased energy expenditure to protect against diet-induced obesity. Indeed, oral administration of L. fermentum LM1016 markedly ameliorated glucose clearance and fatty liver in high-fat diet-fed mice. Moreover, administration of L. fermentum LM1016 markedly decreased inflammation and increased oxidative phosphorylation in gonadal white adipose tissue, as demonstrated by transcriptome analysis. Finally, metabolome analysis showed that metabolites derived from L. fermentum LM1016-attenuated adipocyte differentiation and inflammation in 3T3-L1 preadipocytes. These pronounced metabolic improvements suggested that the application of L. fermentum LM1016 could have clinical applications for the treatment of metabolic syndromes, such as diet-induced obesity.

키워드

Gene expression; Metabolic syndrome; Obesity

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