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Deficiency of peroxiredoxin 2 exacerbates angiotensin II-induced abdominal aortic aneurysm

Experimental & Molecular Medicine 2020년 52권 9호 p.13 ~ 13
정세진, 조민지, 고나영, 김시내, 정인혁, 민정기, 이상학, 박종길, 오구택,
소속 상세정보
정세진 ( Jeong Se-Jin ) - Washington University School of Medicine Department of Medicine
조민지 ( Cho Min-Ji ) - Korea Research Institute of Bioscience and Biotechnology Biotherapeutics Translational Research Center
고나영 ( Ko Na-Young ) - Ewha Womans University Department of Life Sciences
김시내 ( Kim Si-Nai ) - Ewha Womans University Department of Life Sciences
정인혁 ( Jung In-Hyuk ) - Washington University School of Medicine Department of Medicine
민정기 ( Min Jeong-Ki ) - Korea Research Institute of Bioscience and Biotechnology Biotherapeutics Translational Research Center
이상학 ( Lee Sang-Hak ) - Yonsei University College of Medicine Severance Hospital Department of Internal Medicine
박종길 ( Park Jong-Gil ) - Korea Research Institute of Bioscience and Biotechnology Biotherapeutics Translational Research Center
오구택 ( Oh Goo-Taeg ) - Ewha Womans University Department of Life Sciences

Abstract


Abdominal aortic aneurysm (AAA) is an inflammatory vascular disease characterized by structural deterioration of the aorta caused by inflammation and oxidative stress, leading to aortic dilatation and rupture. Peroxiredoxin 2 (PRDX2), an antioxidant enzyme, has been reported as a potential negative regulator of inflammatory vascular diseases, and it has been identified as a protein that is increased in patients with ruptured AAA compared to patients with nonruptured AAA. In this study, we demonstrated that PRDX2 was a pivotal factor involved in the inhibition of AAA progression. PRDX2 levels were increased in AAA compared with those in normal aortas in both humans and mice. Ultrasound imaging revealed that the loss of PRDX2 accelerated the development of AAA in the early stages and increased AAA incidence in mice infused with angiotensin II (Ang II). Prdx2?/? mice infused with Ang II exhibited increased aortic dilatation and maximal aortic diameter without a change in blood pressure. Structural deterioration of the aortas from Prdx2?/? mice infused with Ang II was associated with increases in the degradation of elastin, oxidative stress, and intramural thrombi caused by microhemorrhages, immature neovessels, and the activation of matrix metalloproteinases compared to that observed in controls. Moreover, an increase in inflammatory responses, including the production of cell adhesion molecules and the accumulation of inflammatory cells and proinflammatory cytokines due to PRDX2 deficiency, accelerated Ang II-induced AAA progression. Our data confirm that PRDX2 plays a role as a negative regulator of the pathological process of AAA and suggest that increasing PRDX2 activity may be a novel strategy for the prevention and treatment of AAA.

키워드

Aneurysm

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