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An era of single-cell genomics consortia

Experimental & Molecular Medicine 2020년 52권 9호 p.14 ~ 14
Ando Yoshinari, 권태준, Shin Jay W.,
소속 상세정보
 ( Ando Yoshinari ) - RIKEN Center for Integrative Medical Sciences
권태준 ( Kwon Tae-Jun ) - RIKEN Center for Integrative Medical Sciences
 ( Shin Jay W. ) - RIKEN Center for Integrative Medical Sciences

Abstract


The human body consists of 37 trillion single cells represented by over 50 organs that are stitched together to make us who we are, yet we still have very little understanding about the basic units of our body: what cell types and states make up our organs both compositionally and spatially. Previous efforts to profile a wide range of human cell types have been attempted by the FANTOM and GTEx consortia. Now, with the advancement in genomic technologies, profiling the human body at single-cell resolution is possible and will generate an unprecedented wealth of data that will accelerate basic and clinical research with tangible applications to future medicine. To date, several major organs have been profiled, but the challenges lie in ways to integrate single-cell genomics data in a meaningful way. In recent years, several consortia have begun to introduce harmonization and equity in data collection and analysis. Herein, we introduce existing and nascent single-cell genomics consortia, and present benefits to necessitate single-cell genomic consortia in a regional environment to achieve the universal human cell reference dataset.

키워드

Data integration; Genetics research

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