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Human Cell Atlas and cell-type authentication for regenerative medicine

Experimental & Molecular Medicine 2020년 52권 9호 p.17 ~ 17
Panina Yulia, Karagiannis Peter, Kurtz Andreas, Stacey Glyn N., Fujibuchi Wataru,
소속 상세정보
 ( Panina Yulia ) - Kyoto University Center for iPS Cell Research and Application
 ( Karagiannis Peter ) - Kyoto University Center for iPS Cell Research and Application
 ( Kurtz Andreas ) - Charite-Universitatsmedizin Berlin BIH Center for Regenerative Therapies
 ( Stacey Glyn N. ) - Chinese Academy of Sciences Institute of Zoology
 ( Fujibuchi Wataru ) - Kyoto University Center for iPS Cell Research and Application

Abstract


In modern biology, the correct identification of cell types is required for the developmental study of tissues and organs and the production of functional cells for cell therapies and disease modeling. For decades, cell types have been defined on the basis of morphological and physiological markers and, more recently, immunological markers and molecular properties. Recent advances in single-cell RNA sequencing have opened new doors for the characterization of cells at the individual and spatiotemporal levels on the basis of their RNA profiles, vastly transforming our understanding of cell types. The objective of this review is to survey the current progress in the field of cell-type identification, starting with the Human Cell Atlas project, which aims to sequence every cell in the human body, to molecular marker databases for individual cell types and other sources that address cell-type identification for regenerative medicine based on cell data guidelines.

키워드

Classification and taxonomy; Differentiation; Stem-cell differentiation; Stem-cell research; Translational research

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