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Glutamine reliance in cell metabolism

Experimental & Molecular Medicine 2020년 52권 9호 p.21 ~ 21
유희찬, 유야춘, 성열승, 한정민,
소속 상세정보
유희찬 ( Yoo Hee-Chan ) - Yonsei University College of Pharmacy
유야춘 ( Yu Ya-Chun ) - Yonsei University College of Pharmacy
성열승 ( Sung Yul-Seung ) - Yonsei University College of Pharmacy
한정민 ( Han Jung-Min ) - Yonsei University College of Pharmacy

Abstract


As knowledge of cell metabolism has advanced, glutamine has been considered an important amino acid that supplies carbon and nitrogen to fuel biosynthesis. A recent study provided a new perspective on mitochondrial glutamine metabolism, offering mechanistic insights into metabolic adaptation during tumor hypoxia, the emergence of drug resistance, and glutaminolysis-induced metabolic reprogramming and presenting metabolic strategies to target glutamine metabolism in cancer cells. In this review, we introduce the various biosynthetic and bioenergetic roles of glutamine based on the compartmentalization of glutamine metabolism to explain why cells exhibit metabolic reliance on glutamine. Additionally, we examined whether glutamine derivatives contribute to epigenetic regulation associated with tumorigenesis. In addition, in discussing glutamine transporters, we propose a metabolic target for therapeutic intervention in cancer.

키워드

Cancer metabolism; Metabolomics

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