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Potential roles of stem cell marker genes in axon regeneration

Experimental & Molecular Medicine 2021년 53권 1호 p.1 ~ 7
이진영, Cho Yong-Cheol,
소속 상세정보
이진영 ( Lee Jin-Young ) - Korea University Department of Life Sciences
 ( Cho Yong-Cheol ) - Korea University Department of Life Sciences

Abstract


Axon regeneration is orchestrated by many genes that are differentially expressed in response to injury. Through a comparative analysis of gene expression profiling, injury-responsive genes that are potential targets for understanding the mechanisms underlying regeneration have been revealed. As the efficiency of axon regeneration in both the peripheral and central nervous systems can be manipulated, we suggest that identifying regeneration-associated genes is a promising approach for developing therapeutic applications in vivo. Here, we review the possible roles of stem cell marker- or stemness-related genes in axon regeneration to gain a better understanding of the regeneration mechanism and to identify targets that can enhance regenerative capacity.

키워드

Molecular neuroscience; Peripheral nervous system; Spinal cord injury

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