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Cochlin-cleaved LCCL is a dual-armed regulator of the innate immune response in the cochlea during inflammation

BMB Reports 2020년 53권 9호 p.449 ~ 452
류형준, 배성훈, 정진세, 현영민,
소속 상세정보
류형준 ( Rhyu Hyeong-Jun ) - Yonsei University College of Medicine Department of Medicine
배성훈 ( Bae Seong-Hoon ) - Yonsei University College of Medicine Department of Otorhinolaryngology
정진세 ( Jung Jin-Sei ) - Yonsei University College of Medicine Department of Otorhinolaryngology
현영민 ( Hyun Young-Min ) - Yonsei University College of Medicine Department of Anatomy

Abstract


The inner ear is a complex and delicate structure composed of the cochlea and the vestibular system. To maintain normal auditory function, strict homeostasis of the inner ear is needed. A proper immune response against infection, thus, is crucial. Also, since excessive immune reaction can easily damage the normal architecture within the inner ear, the immune response should be fine regulated. The exact mechanism how the inner ear’s immune response, specifically the innate immunity, is regulated was unknown. Recently, we reported a protein selectively localized in the inner ear during bacterial infection, named cochlin, as a possible mediator of such regulation. In this review, the immunological function of cochlin and the mechanism behind its role within inner ear immunity is summarized. Cochlin regulates innate immunity by physically entrapping pathogens within scala tympani and recruiting innate immune cells. Such mechanism enables efficient removal of pathogen while preserving the normal inner ear structure from inflammatory damage.

키워드

Cochlin; LCCL; Immune regulation; Infection; Inner ear immunity

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