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Implications of telomerase reverse transcriptase in tumor metastasis

BMB Reports 2020년 53권 9호 p.458 ~ 465
Zou Yongkang, Cong Yu-Sheng, Zhou Junzhi,
소속 상세정보
 ( Zou Yongkang ) - Shenzhen Bay Laboratory Institute of Cancer Research
 ( Cong Yu-Sheng ) - Hangzhou Normal University School of Medicine Institute of Aging Research
 ( Zhou Junzhi ) - Hangzhou Normal University School of Medicine Institute of Aging Research

Abstract


Metastasis is the main culprit of the great majority of cancerrelated deaths. However, the complicated process of the invasion-metastasis cascade remains the least understood aspect of cancer biology. Telomerase plays a pivotal role in bypassing cellular senescence and sustaining the cancer progression by maintaining telomere homeostasis and genomic integrity. Telomerase reverse transcriptase (TERT) exerts a series of fundamental functions that are independent of its enzymatic cellular activity, including proliferation, inflammation, epithelia-mesenchymal transition (EMT), angiogenesis, DNA repair, and gene expression. Accumulating evidence indicates that TERT may facilitate most steps of the invasion-metastasis cascade. In this review, we summarize important advances that have revealed some of the mechanisms by which TERT facilitates tumor metastasis, providing an update on the non-canonical functions of telomerase beyond telomere maintaining.

키워드

Cellular senescence; EMT; Metastasis; Telomerase; TERT

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