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Improved human hematopoietic reconstitution in HepaRG co-transplanted humanized NSG mice

BMB Reports 2020년 53권 9호 p.466 ~ 471
김진, 류보경, 김욱진, 김창환, 허경행, 김시윤, 박재학,
소속 상세정보
김진 ( Kim Jin ) - Seoul National University College of Veterinary Medicine Department of Laboratory Animal Medicine
류보경 ( Ryu Bo-Kyeong ) - Seoul National University College of Veterinary Medicine Department of Laboratory Animal Medicine
김욱진 ( Kim Uk-Jin ) - Seoul National University College of Veterinary Medicine Department of Laboratory Animal Medicine
김창환 ( Kim Chang-Hwan ) - Agency for Defense Development
허경행 ( Hur Gyeung-Haeng ) - Agency for Defense Development
김시윤 ( Kim C-Yoon ) - Konkuk University School of Medicine Department of Stem Cell Biology
박재학 ( Park Jae-Hak ) - Seoul National University College of Veterinary Medicine Department of Laboratory Animal Medicine

Abstract


Several humanized mouse models are being used to study humanspecific immune responses and diseases. However, the pivotal needs of fetal tissues for the humanized mice model have been huddled because of the demand for ethical and medical approval. Thus, we have verified the hematopoietic and immunomodulatory function of HepaRG and developed a new and easy humanized mouse model to replace the use of fetal liver tissue. HepaRG co-transplanted Hu-NSG mice significantly increased CD45+ lymphocytes and CD19+ B cells and CD3+ T cells than normal Hu-NSG, suggesting enhanced reconstitution of the human immune system. These results have improved the applicability of humanized mice by developing new models easily accessible.

키워드

HepaRG cells; HSC; Humanized mouse; NSG

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