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산화적 스트레스에 대한 여주(Momordica charantia Linn.)잎의항산화 활성 및 간세포 보호능

Antioxidant and Hepatoprotective Activities of Bitter Melon (Momordica charantia Linn.) Leaves against Oxidative Stress

한국식생활문화학회지 2020년 35권 6호 p.597 ~ 604
전아영, 천원영, 윤지민, 김대정, 김영화,
소속 상세정보
전아영 ( Jeon Ah-Yeong ) - Kyungsung University Department of Food Science and Biotechnology
천원영 ( Cheon Won-Young ) - Kyungsung University Department of Food Science and Biotechnology
윤지민 ( Yoon Ji-Min ) - Kyungsung University Department of Food Science and Biotechnology
김대정 ( Kim Dae-Jung ) - National Agricultural products Quality management Service Experiment Research Institute
김영화 ( Kim Young-Hwa ) - Kyungsung University School of Food Biotechnology & Nutrition

Abstract


This study examined the bioactive compound content and the antioxidant activities of bitter melon (Momordica charantiaLinn.) leaves. The content of vitamin C, beta-carotene, and total carotenoids was 69.77, 45.68, and 65.08 mg/100 g,respectively. To investigate the antioxidant capacity, bitter melon leaves were extracted using various concentrations ofethanol (60, 80, or 100%). Highest content of total polyphenols (18.07 mg gallic acid equivalent/g) and flavonoids (4.53 mgcathechin equivalent/g) was found in the 100% ethanolic extract of the leaves (E100). Also, the E100 extract showed thehighest levels of 2,2'azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) and α-α-diphenyl-β-picrylhydrazyl (DPPH)free radical scavenging activities. Reducing power was also the highest (39.21 mg Trolox equivalent/g) in E100 extract. TheE100 extract effectively inhibited lipid peroxidation by 91.45% compared to the control group. Also, the E100 extractshowed a cytoprotective effect against oxidative stress in HepG2 cells and decreased the generation of intracellular reactiveoxygen species. These results suggest that bitter melon leaves could be regarded as a potential source of natural antioxidants.

키워드

Bitter melon leaf; radical scavenging activity; hepatoprotective effect; intracellular reactive oxygen species; antioxidant

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