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몽골과 미얀마 식물 14종의 3T3-L1 및 HepG2 세포에서 지질 축적 억제효과

Inhibitory Effects of 14 Plants from Mongolia and Myanmar on Lipid Accumulation in 3T3-L1 and HepG2 Cells

한국식생활문화학회지 2021년 36권 1호 p.130 ~ 142
전익조, 김건희,
소속 상세정보
전익조 ( Chun Ik-Jo ) - Duksung Women’s University Department of Bio-Health Convergence Major
김건희 ( Kim Gun-Hee ) - Duksung Women’s University Department of Bio-Health Convergence Major

Abstract


This study examined the antioxidative and lipid accumulation inhibitory effects of 14 plants from Mongolia and Myanmaron 3T3-L1 and HepG2 cells. The total phenolic and flavonoid contents (TPC and TFC) of 14 plant extracts were measured,and the antioxidative activities were analyzed using DPPH, ABTS, FRAP, and ORAC. After measuring the pancreatic lipaselevels and performing the thiobarbituric acid assay, the degree of lipid accumulation was determined by lipid (Oil Red O)staining and triglyceride assay in 3T3-L1 and HepG2 cells. M. paniculate (259.43 mgGAE/g) and C. benghalensis (130.78mgNAE/g) had the highest TPC and TFC, respectively, among the 14 plants. R. acicularis Lindl. had the highest antioxidantactivity in DPPH. The ABTS, FRAP, and ORAC results showed that the antioxidant activity of 11 species was higher thanthat of the positive control. The pancreatic lipase inhibitory effect of C. angustifolium Scop. was reduced to 23.65% at 0.1mg/mL, and the level of lipid peroxidation of C. abrorescens Lam. was 0.63 nmol/mg. Five selected plants inhibited the lipidaccumulation and triglyceride content, respectively, in 3T3-L1 and HepG2 cells. These results provide scientific evidence fordeveloping functional foods using 14 plants from Mongolia and Myanmar, which have antioxidant activities and lipidaccumulation reduction effects.

키워드

Mongolia; myanmar; antioxidant; lipid accumulation; 3T3-L1; hepG2

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