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Whitening effect of novel peptide mixture by regulating melanosome biogenesis, transfer and degradation

Korean Journal of Physiology & Pharmacology 2021년 25권 1호 p.15 ~ 26
이응지, 김잔디, 정민경, 이영민, 정용지, 김은미,
소속 상세정보
이응지 ( Lee Eung-Ji ) - Caregen R&D Center
김잔디 ( Kim Jan-Di ) - Caregen R&D Center
정민경 ( Jeong Min-Kyeong ) - Caregen R&D Center
이영민 ( Lee Young-Min ) - Caregen R&D Center
정용지 ( Chung Yong-Ji ) - Caregen R&D Center
김은미 ( Kim Eun-Mi ) - Caregen R&D Center

Abstract


Peptides are short chain of amino acids linked by peptide bonds. They are widely used as effective and biocompatible active ingredients in cosmetic industry. In this study, we developed novel peptide mixture and identified its anti-pigmentation effect on melanocytes and keratinocytes. Our results revealed that peptide mixture inhibited melanosome biogenesis through the regulation of microphthalmia-associated transcription factor, a key factor of melanogenesis in melanocytes. And we observed that peptide mixture inhibited melanosome uptake through the reduction of protease-activated receptor 2, a phagocytosis-related receptor in keratinocytes. Furthermore, peptide mixture activated autophagy system resulting in degradation of transferred melanosomes in keratinocytes. The anti-pigmentation effect of multi-targeting peptide mixture was assessed in a human skin equivalent model (MelanoDerm). Melanin contents in epidermal layer were significantly decreased by topical treatment of peptide mixture, suggesting that it can be applied as a novel cosmetics material having a whitening function.

키워드

Autophagy; Melanosome; Microphthalmia-associated transcription factor PAR-2; Peptide

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