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The effect of adenosine triphosphate on propofol-induced myopathy in rats: a biochemical and histopathological evaluation

Korean Journal of Physiology & Pharmacology 2021년 25권 1호 p.69 ~ 77
Erdem Kezban Tuna Ozkaloglu, Bedir Zehra, Ates Irem, Kuyrukluyildiz Ufuk, Coban Taha Abdulkadir, Yazici Gulce Naz, Arslan Yusuf Kemal, Suleyman Zeynep, Suleyman Halis,
소속 상세정보
 ( Erdem Kezban Tuna Ozkaloglu ) - Balikesir Ataturk City Hospital Anesthesiology and Reanimation Clinic
 ( Bedir Zehra ) - Erzurum Nenehatun Maternity Hospital Department of Anesthesiology and Reanimation
 ( Ates Irem ) - Ataturk University Faculty of Medicine Department of Anesthesiology and Reanimation
 ( Kuyrukluyildiz Ufuk ) - Erzincan Binali Yildirim University Faculty of Medicine Department of Anesthesiology and Reanimation
 ( Coban Taha Abdulkadir ) - Erzincan Binali Yildirim University Faculty of Medicine Department of Medical Biochemistry
 ( Yazici Gulce Naz ) - Erzincan Binali Yildirim University Faculty of Medicine Department of Histology and Embryology
 ( Arslan Yusuf Kemal ) - Erzincan Binali Yildirim University Faculty of Medicine Department of Biostatistics
 ( Suleyman Zeynep ) - Erzincan Binali Yildirim University Faculty of Health Sciences Department of Nursing
 ( Suleyman Halis ) - Erzincan Binali Yildirim University Faculty of Medicine Department of Pharmacology

Abstract


Propofol infusion syndrome characterized by rhabdomyolysis, metabolic acidosis, kidney, and heart failure has been reported in long-term propofol use for sedation. It has been reported that intracellular adenosine triphosphate (ATP) is reduced in rhabdomyolysis. The study aims to investigate the protective effect of ATP against possible skeletal muscle damage of propofol in albino Wistar male rats biochemically and histopathologically. PA-50 (n = 6) and PA-100 (n = 6) groups of animals was injected intraperitoneally to 4 mg/kg ATP. An equal volume (0.5 ml) of distilled water was administered intraperitoneally to the P-50, P-100, and HG groups. One hour after the administration of ATP and distilled water, 50 mg/kg propofol was injected intraperitoneally to the P-50 and PA-50 groups. This procedure was repeated once a day for 30 days. The dose of 100 mg/kg propofol was injected intraperitoneally to the P-100 and PA-100 groups. This procedure was performed three times with an interval of 1 days. Our experimental results showed that propofol increased serum CK, CK-MB, creatinine, BUN, TP I, ALT, AST levels, and muscle tissue MDA levels at 100 mg/kg compared to 50 mg/kg and decreased tGSH levels. At a dose of 100 mg/ kg, propofol caused more severe histopathological damage compared to 50 mg/ kg. It was found that ATP prevented propofol-induced muscle damage and organ dysfunction at a dose of 50 mg/kg at a higher level compared to 100 mg/kg. ATP may be useful in the treatment of propofol-induced rhabdomyolysis and multiple organ damage.

키워드

Adenosine triphosphate; Muscle; Myopathy; Propofol; Rat; Rhabdomyolysis

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