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Effects of a Psychobiotic Supplement on Serum Brain-derived Neurotrophic Factor Levels in Depressive Patients: A Post Hoc Analysis of a Randomized Clinical Trial

Journal of Neurogastroenterology and Motility 2020년 26권 4호 p.486 ~ 495
Heidarzadeh-Rad Nazanin, Gokmen-Ozel Hulya, Kazemi Asma, Almasi Negin, Djafarian Kurosh,
소속 상세정보
 ( Heidarzadeh-Rad Nazanin ) - Hacettepe University Faculty of Health Sciences Department of Nutrition and Dietetics
 ( Gokmen-Ozel Hulya ) - Hacettepe University Faculty of Health Sciences Department of Nutrition and Dietetics
 ( Kazemi Asma ) - Shiraz University of Medical Sciences Nutrition Research Center
 ( Almasi Negin ) - Hacettepe University Faculty of Health Sciences Department of Nutrition and Dietetics
 ( Djafarian Kurosh ) - Tehran University of Medical Sciences School of Nutritional Sciences and Dietetics Department of Clinical Nutrition

Abstract


Background/Aims: Psychobiotics are probiotics or prebiotics that, upon ingestion in adequate amounts, yield positive influence on mental health via microbiota-gut-brain axis regulation to modulate the circulating cytokines, chemokines, neurotransmitters, or neurotrophins levels. We have recently shown that a psychobiotic combination (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175; CEREBIOME) significantly improved depression symptoms in patients with depression. Recent animal data suggest the influence of the gut microbiota on brain-derived neurotrophic factor (BDNF), which was shown to correlate with antidepressant response in depressive patients. Therefore, we conducted this exploratory post hoc analysis of BDNF levels to clarify the mechanism of action of this psychobiotic in our cohort.

Methods: Our study was a double-blind, randomized controlled trial of patients with low-to-moderate depression receiving either a probiotic combination, prebiotic or placebo. From the 110 patients randomized in the trial, 78 were included in this post hoc analysis (probiotic, n = 28; prebiotic and placebo, n = 25). We compared serum BDNF levels from participants at baseline and endpoint, and assessed the Pearson correlation between depression severity and BDNF levels for each intervention.

Results: We found that post-intervention BDNF levels were significantly different between groups (P < 0.001). Furthermore, BDNF levels increased significantly in the probiotic group compared to both the prebiotic (P < 0.001) and placebo groups (P = 0.021), which inversely correlated with depression severity compared to placebo (ANOVA/ANCOVA, P = 0.012; Pearson, r = ?0.79, P < 0.001). In the prebiotic group, BDNF levels reduced but not significantly compared with placebo group (P > 0.05).

Conclusion: Eight-week supplementation with B. longum and L. helveticus in depressive patients improved depression symptoms, possibly by increasing BDNF levels.

키워드

Brain-derived neurotrophic factor; Depression; Prebiotics; Probiotics

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