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Dysosteogenesis in the Mandibular Bone of SAMP1/Klotho-Deficient Mice

대한구강악안면병리학회지 2020년 44권 4호 p.103 ~ 112
육종인, Toan Nguyen Khanh, 서요섭, 유상준, 안상건,
소속 상세정보
육종인 ( Yook Jong-In ) - Yonsei University College of Dentistry Department of Oral Pathology
 ( Toan Nguyen Khanh ) - Chosun University School of Dentistry Department of Oral Pathology
서요섭 ( Seo Yo-Seob ) - Chosun University School of Dentistry Department of Oral and Maxillofacial Radiology
유상준 ( Yu Sang-Joun ) - Chosun University School of Dentistry Department of Periodontology
안상건 ( Ahn Sang-Gun ) - Chosun University School of Dentistry Department of Oral Pathology

Abstract


Aging is a physiological change that leads to a decline in biological functions from metabolic stress. To investigate the effect of aging on mandibular bone formation, we created SAMP1/Klotho-deficient mice and performed micro-computed tomography (micro-CT) and histology analyses in 4-or 8 week-old SAMP1/kl -/- mice. SAMP1/kl -/- mice exhibited extensive inflammation, tissue calcification, and abnormal mandibular bone development. Using micro-CT analysis, SAMP1/kl -/- mice displayed a loss of incisor roots and irregular dentinal tubule formation, as well as calcification within the pulp root canal. Furthermore, the mandibular ramus showed extensive ground glass appearance in SAMP1/kl -/- mice. In histological analysis, we found calcified skeletal structures and dysplastic bone formation in SAMP1/kl -/- mice. These results provide an understanding of the pathologic alterations of aging-related mandibular bone. SAMP1/kl -/- mice may serve as a novel model for dysosteogenesis in mandibular bone development.

키워드

SAMP1/ Klotho; Aging; Dysosteogenesis; Mandibular bone; Bone development

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