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Vinpocetine inhibits the proliferation and induces apoptosis in human colon cancer cells

International Journal of Oral Biology 2021년 46권 1호 p.7 ~ 14
김미경, 박현주, 김연, 김용일, 배수경, 김형준, 배문경,
소속 상세정보
김미경 ( Kim Mi-Kyoung ) - Pusan National University School of Dentistry Department of Oral Physiology
박현주 ( Park Hyun-Joo ) - Pusan National University School of Dentistry Department of Oral Physiology
김연 ( Kim Yeon ) - Pusan National University School of Dentistry Department of Oral Physiology
김용일 ( Kim Yong-Il ) - Pusan National University School of Dentistry Department of Orthodontics
배수경 ( Bae Soo-Kyung ) - Pusan National University School of Dentistry Department of Dental Pharmacology
김형준 ( Kim Hyung-Joon ) - Pusan National University School of Dentistry Department of Oral Physiology
배문경 ( Bae Moon-Kyoung ) - Pusan National University School of Dentistry Department of Oral Physiology

Abstract


Vinpocetine induces anti-inflammatory effects in various inflammatory diseases via the inhibition of phosphodiesterase type-1-independent nuclear factor-κB signaling pathway and the release of inflammatory cytokines. In this study, we investigated the effect of vinpocetine on the proliferation of colon cancer cells and its underlying molecular mechanisms. Our data showed that vinpocetine inhibits the viability and proliferation of colon cancer cells. Vinpocetine treatment induced cell death in HCT116 cells, which the percentages of sub-G1 phase were significantly increased, and the apoptosis-related genes were regulated after HCT116 cells were treated with vinpocetine. In sum, our findings indicated that vinpocetine could be a therapeutically useful candidate in the treatment of colon cancer.

키워드

Vinpocetine; Colon cancer cells; Apoptosis; Proliferation

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