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2000년도 이후에 진단된 중심성 폐암과 말초성 폐암의 임상적 차이

Characteristics of Peripheral versus Central Lung Cancer Since 2000

고신대학교 의과대학 학술지 2014년 29권 1호 p.47 ~ 52
옥소영, 장태원, 한유진, 여고은, 김은정, 이원형, 김남규,
소속 상세정보
옥소영 ( Ock So-Young ) - 고신대학교 의과대학 내과학교실
장태원 ( Jang Tae-Won ) - 고신대학교 의과대학 내과학교실
한유진 ( Han You-Jin ) - 고신대학교 의과대학 내과학교실
여고은 ( Yeo Go-Eun ) - 고신대학교 의과대학 내과학교실
김은정 ( Kim Eun-Jeong ) - 고신대학교 의과대학 내과학교실
이원형 ( Lee Weon-Hyoung ) - 고신대학교 의과대학 내과학교실
김남규 ( Kim Nam-Kyu ) - 고신대학교 의과대학 내과학교실

Abstract


Objectives: The aim of this study was to explore the changes of bronchoscopic features according to epidemiologic change of lung cancer.

Methods: We performed a retrospective review of the clinical characteristics of 1,139 lung cancer patient who underwent bronchoscopy at Kosin University Hospital from January 2000 to December 2010.

Results: The age of patients increased significantly during the last decade (P < 0.001). The most common histological type was adenocarcinoma (38.1%), followed by squamous carcinoma (35.7%) and small cell carcinoma (15.3%). There was an increasing incidence of adenocarcinoma over the time (P < 0.001). Bronchoscopic feature were divided into two classes; central type, peripheral type. The peripheral type was predominant (62.3%). The proportion of peripheral type has been increased in process of time (49.7% vs. 63.7% vs. 73.7%; P < 0.01). Among the major histopathologic type of lung cancer, adenocarcinoma (81.3%) and unclassifiable non-small-cell lung cancer (73.4%), small cell carcinoma (56.9%) were associated with preferential occurrence of peripheral type. Squamous cell carcinoma of the lung more often arised in central type (59%). However, the proportion of peripheral squamous cell carcinoma has been increased. On the subgroup analysis, the median survival time of peripheral type with adenocarcinoma and small cell carcinoma were longer than central type (P < 0.05).

Conclusions: The age of the lung cancer patients at diagnosis was getting older. The most frequent histopathologic type was adenocarcinoma. The proportion of peripheral type lung cancer gradually increased over the time. The survival time of peripheral type lung cancer was longer than central type.

키워드

Bronchoscopy; Lung cancer

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