잠시만 기다려 주세요. 로딩중입니다.

죽엽황금복합추출물 BS21의 고지방식이 유도 비만 동물모델에서의 지방생성 및 고요산혈증 개선 효과

BS21, a combination of Phyllostachys pubescens and Scutellaria baicalensis extracts, reduces adiposity and hyperuricemia in high-fat diet-induced obese mice

대한본초학회지 2020년 35권 5호 p.1 ~ 12
성윤영, 이영실, 김승형, 김동선,
소속 상세정보
성윤영 ( Sung Yoon-Young ) - Korea Institute of Oriental Medicine Center of Herbal Resources Research
이영실 ( Lee Young-Sil ) - Korea Institute of Oriental Medicine Center of Herbal Resources Research
김승형 ( Kim Seung-Hyung ) - Daejeon University Institute of Traditional Medicine and Bioscience
김동선 ( Kim Dong-Seon ) - Korea Institute of Oriental Medicine Center of Herbal Resources Research

Abstract


Objectives : Phyllostachys pubescens and Scutellaria baicalensis are considered to be effective in promoting blood circulation in traditional medicine. In this study, we examined whether a mixture of P. pubescens leaves and S. baicalensis root (BS21) had any anti-obesity, anti-hyperlipidemia, or anti-hyperuricemia effects and the possible mechanisms of action.

Methods : We examined the effects of BS21 in high-fat diet (HFD)-induced obese mice. Mice were fed HFD with BS21 (75, 150, or 300 ㎎/㎏) or Garcinia cambogia extracts (245 ㎎/㎏) as a positive control for 8 weeks. At the end of 8 weeks, body weight, liver and adipose weight, adipocyte size, plasma lipid profiles, adipokine and uric acid levels, and adipose tissue expression levels in obesity and uric acid production-related genes were examined.

Results : BS21 decreased body weight gain, white adipose tissue, liver weight, adipocyte size, and liver triglyceride accumulation. It also reduced levels of plasma glucose, triglycerides, non-esterified fatty acids, total cholesterol, low-density lipoprotein cholesterol, alanine transaminase, leptin, and uric acid. In contrast, BS21 increased adiponectin levels. Furthermore, BS21 decreased the expression levels of adipogenesis-related genes, such as peroxisome proliferator-activated receptor γ, sterol regulatory element binding protein-1c, and fatty acid synthase, as well as xanthine oxidoreductase, which is involved in uric acid production.

Conclusions : These results suggest that BS21 may exert anti-obesity, anti-hyperlipidemia, and anti-hyperuricemia effects in HFD-induced obese mice by regulating the expression of xanthine oxidoreductase and adipogenesis-related genes.

키워드

adipogenesis; hyperuricemia; mixture; obesity; xanthine oxidoreductase

원문 및 링크아웃 정보

 

등재저널 정보

KCI