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감초 신품종 및 약전 수재감초의 항알러지 효과 비교 연구

The Comparative Study of Anti-allergic Effect by Glycyrrhiza New Varietiesand Official Compendia

대한본초학회지 2020년 35권 5호 p.13 ~ 21
강윤미, 김원남, 진종식, 이종현, 장재기, 이정훈, 안효진,
소속 상세정보
강윤미 ( Kang Yun-Mi ) - Sangji University College of Korean Medicine Department of Pharmacology
김원남 ( Kim Won-Nam ) - Semyung University College of Korean Medicine Division of Pharmacology
진종식 ( Jin Jong-Sik ) - Chonbuk National University Department of Oriental Medicine Resources
이종현 ( Lee Jong-Hyun ) - Dongduk Women’s University College of Pharmacy
장재기 ( Chang Jae-Ki ) - RDA NIHHS Department of Herbal Crop Research
이정훈 ( Lee Jeong-Hoon ) - RDA NIHHS Department of Herbal Crop Research
안효진 ( An Hyo-Jin ) - Sangji University College of Korean Medicine Department of Pharmacology

Abstract


Objective : The genus Glycyrrhiza has been used in food and traditional herbal medicine. Many experimental studies reported that Glycyrrhiza species possess several pharmacological properties. Glycyrrhiza new varieties WONGAM and SINWONGAM have been developed by Korea Rural Development Administration doing research for registration on Ministry of Food and Drug Safety. During the evaluations about pharmacological effect of Glycyrrhiza new varieties WONGAM and SINWONGAM, we focused the anti-allergic effect in this study.

Methods : We investigated the anti-allergic effect of WONGAM and SINWONGAM compared with Glycyrrhiza uralensis Fischer and G. glabra L. using anti-dinitrophenyl-immunoglobulin E (IgE)/human serum albumin-stimulated RBL- 2H3 cells, phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated HMC-1 cells and compound 48/80-induced anaphylaxis mice model. We analyzed the effect on the expression of various cytokines, and IgE from mast cells and the underlying molecular mechanisms of WONGAM and SINWONGAM in presented models.

Results : WONGAM and SINWONGAM showed the inhibitory effect on the histamine release from rat peritoneal mast cells or human mast cells without cytotoxicity. WONGAM and SINWONGAM blocked anaphylactic shock and decreased the IgE production. Furthermore, WONGAM and SINWONGAM inhibited the productions of TNF-α and IL-6 in compound 48/80-induced anaphylaxis mice model.

Conclusion : These results indicated that WONGAM and SINWONGAM would have protect effect on allergic responses through the inhibition of allergic mediators and pro-inflammatory cytokines. This study may facilitate the development on Glycyrrhiza new varieties for allergy.

키워드

Allergic response; Glycyrrhiza;Glycyrrhiza new varieties; Mast cell; Anaphylaxis

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