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추출 용매를 달리한 생강 추출물에 대한 생리활성의 비교 평가 연구

Comparative evaluation on biological activities of Ziingiber officinale Roscoe extracted from different solvents

대한본초학회지 2021년 36권 2호 p.19 ~ 29
김소영, 최문열, 도은주, 김미려,
소속 상세정보
김소영 ( Kim So-Young ) - Daegu Haany University College of Oriental Medicine Department of Herbal Pharmacology
최문열 ( Choi Moon-Yeol ) - Daegu Haany University College of Oriental Medicine Department of Herbal Pharmacology
도은주 ( Do Eun-Ju ) - Daegu Technopark Oriental Medicine Industry Support Center
김미려 ( Kim Mi-Ryeo ) - Daegu Haany University College of Oriental Medicine Department of Herbal Pharmacology

Abstract


Objective : This study was designed to investigate anti-oxidative, anti-aging and anti-inflammatory activities of Zingiber officinale Roscoe water (ZD) and 50% ethanol extracts (ZE).

Method : The antioxidant capacity of ZD or ZE was analyzed by DPPH, ABTS scavenging activities and reducing power, respectively. The anti-aging efficacy was performed with tyrosinase and collagenase inhibition activities. The anti-inflammatory activities were confirmed through inhibition of nitric oxide production and TNF-α expression in LPStreated Raw 264.7 cells.

Result : As a result of measuring DPPH and ABTS radical scavenging activities, both ZD and ZE extracts increased in concentration-dependent manners. The ABTS radical scavenging activities of water and 50% ethanol extract were similar to that of positive control at high concentration. On reducing power, both ZD and ZE showed higher activities than the positive control at high concentration. On inhibition activities of tyrosinase and collagenase both ZD and ZE showed the large inhibition rates at low concentration. Also, the inhibitory efficacy of ZD on NO and TNF-α production was better than ZE in RAW 264.7 cells.

Conclusion : These results suggest that ZD and ZE have anti-oxidative, anti-aging and anti-inflammatory effects in vitro. Especially, ZD was more effective than ZE. Thus, Ginger extract is considered to be highly useful as a cosmetic or food material with anti-oxidative, anti-aging (prevention of whitening and wrinkle) and anti-inflammatory effects. Also these effects may vary depending on the extraction solvent.

키워드

Zingiber officinale Roscoe; anti-aging; anti-oxidant; anti-inflammation

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