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Intervention with kimchi microbial community ameliorates obesity by regulating gut microbiota

Journal of Microbiology 2020년 58권 10호 p.859 ~ 867
박성은, 권선재, 조광문, 서승호, 김은주, 운노타쯔야, Bok So-Hyeon, 박대훈, 손홍석,
소속 상세정보
박성은 ( Park Seong-Eun ) - Dongshin University College of Korean Medicine
권선재 ( Kwon Sun-Jae ) - AccuGene Inc.
조광문 ( Cho Kwang-Moon ) - AccuGene Inc.
서승호 ( Seo Seung-Ho ) - Dongshin University College of Korean Medicine
김은주 ( Kim Eun-Ju ) - Dongshin University College of Korean Medicine
운노타쯔야 ( Unno Tatsuya ) - Jeju National University Faculty of Biotechnology
 ( Bok So-Hyeon ) - Dongshin University Department of Nursing
박대훈 ( Park Dae-Hun ) - Dongshin University Department of Nursing
손홍석 ( Son Hong-Seok ) - Dongshin University College of Korean Medicine

Abstract


The objective of this study was to evaluate anti-obesity effects of kimchi microbial community (KMC) on obesity and gut microbiota using a high fat diet-induced mouse model compared to effects of a single strain. Administration of KMC decreased body weight, adipose tissue, and liver weight gains. Relative content of Muribaculaceae in the gut of the KMC-treated group was higher than that in the high-fat diet (HFD) group whereas relative contents of Akkermansiaceae, Coriobacteriaceae, and Erysipelotrichaceae were lower in KMC-treated group. Metabolic profile of blood was found to change differently according to the administration of KMC and a single strain of Lactobacillus plantarum. Serum metabolites significantly increased in the HFD group but decreased in the KMC-treated group included arachidic acid, stearic acid, fumaric acid, and glucose, suggesting that the administration of KMC could influence energy metabolism. The main genus in KMC was not detected in guts of mice in KMC-treated group. Since the use of KMC has advantages in terms of safety, it has potential to improve gut microbial community for obese people.

키워드

obesity; kimchi microbial community; metabolomics; amplicon sequencing; microbiota

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