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Minor and major circRNAs in virus and host genomes

Journal of Microbiology 2021년 59권 3호 p.324 ~ 331
Lou Zhihao, Zhou Rui, Su Yinghua, Liu Chun, Ruan Wenting, 전체옥, Han Xiao, Lin Chun, Jia Baolei,
소속 상세정보
 ( Lou Zhihao ) - Fuzhou University College of Biological Science and Engineering
 ( Zhou Rui ) - Fujian Medical University Mengchao Hepatobiliary Hospital
 ( Su Yinghua ) - Fuzhou University College of Biological Science and Engineering
 ( Liu Chun ) - Fuzhou University College of Biological Science and Engineering
 ( Ruan Wenting ) - Chung-Ang University Department of Life Science
전체옥 ( Jeon Che-Ok ) - Chung-Ang University Department of Life Science
 ( Han Xiao ) - Fuzhou University College of Biological Science and Engineering
 ( Lin Chun ) - Fujian Medical University Mengchao Hepatobiliary Hospital
 ( Jia Baolei ) - Chung-Ang University Department of Life Science

Abstract


As a special type of noncoding RNA, circular RNAs (circRNAs) are prevalent in many organisms. They can serve as sponges for microRNAs and protein scaffolds, or templates for protein translation, making them linked to cellular homeostasis and disease progression. In recent years, circRNAs have been found to be abnormally expressed during the processes of viral infection and pathogenesis, and can help a virus escape the immune response of a host. Thus, they are now considered to play important functions in the invasion and development of viruses. Moreover, the potential application of circRNAs as biomarkers of viral infection or candidates for therapeutic targeting deserves consideration. This review summarizes circRNAs in the transcriptome, including their classification, production, functions, and value as biomarkers. This review paper also describes research progress on circRNAs in viral infection (mainly hepatitis B virus, HIV, and some human herpes viruses) and aims to provide new ideas for antiviral therapies targeting circRNAs.

키워드

ncRNAs; circRNAs; virus; HIV; HBV

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