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Trans-acting regulators of ribonuclease activity

Journal of Microbiology 2021년 59권 4호 p.341 ~ 359
이재진, 이민호, 이강석,
소속 상세정보
이재진 ( Lee Jae-Jin ) - Chung-Ang University Department of Life Science
이민호 ( Lee Min-Ho ) - Chung-Ang University Department of Life Science
이강석 ( Lee Kang-Seok ) - Chung-Ang University Department of Life Science

Abstract


RNA metabolism needs to be tightly regulated in response to changes in cellular physiology. Ribonucleases (RNases) play an essential role in almost all aspects of RNA metabolism, including processing, degradation, and recycling of RNA molecules. Thus, living systems have evolved to regulate RNase activity at multiple levels, including transcription, post-transcription, post-translation, and cellular localization. In addition, various trans-acting regulators of RNase activity have been discovered in recent years. This review focuses on the physiological roles and underlying mechanisms of trans-acting regulators of RNase activity.

키워드

RNase regulator; RNase stability; post-translational regulation of RNase; trans-acting regulator; proteolysis

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