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The Prognostic Value of 18F-Fluorodeoxyglucose PET/CT in the Initial Assessment of Primary Tracheal Malignant Tumor: A Retrospective Study

Korean Journal of Radiology 2021년 22권 3호 p.425 ~ 434
Shao Dan, Gao Qiang, Cheng You, Du Dong-Yang, Wang Si-Yun, Wang Shu-Xia,
소속 상세정보
 ( Shao Dan ) - Guangdong Academy of Medical Sciences Guangdong Provincial People’s Hospital Department of PET Center
 ( Gao Qiang ) - Guangzhou First People’s Hospital Department of Radiology
 ( Cheng You ) - Guangdong Academy of Medical Sciences Guangdong Provincial People’s Hospital Department of PET Center
 ( Du Dong-Yang ) - Southern Medical University School of Biomedical Engineering
 ( Wang Si-Yun ) - Guangdong Academy of Medical Sciences Guangdong Provincial People’s Hospital Department of PET Center
 ( Wang Shu-Xia ) - Guangdong Academy of Medical Sciences Guangdong Provincial People’s Hospital Department of PET Center

Abstract


Objective: To investigate the potential value of 18F-fluorodeoxyglucose (FDG) PET/CT in predicting the survival of patients with primary tracheal malignant tumors.

Materials and Methods: An analysis of FDG PET/CT findings in 37 primary tracheal malignant tumor patients with a median follow-up period of 43.2 months (range, 10.8?143.2 months) was performed. Cox proportional hazards regression analyses were used to assess the associations between quantitative 18F-FDG PET/CT parameters, other clinic-pathological factors, and overall survival (OS). A risk prognosis model was established according to the independent prognostic factors identified on multivariate analysis. A survival curve determined by the Kaplan-Meier method was used to assess whether the prognosis prediction model could effectively stratify patients with different risks factors.

Results: The median survival time of the 37 patients with tracheal tumors was 38.0 months, with a 95% confidence interval of 10.8 to 65.2 months. The 3-year, 5-year and 10-year survival rate were 54.1%, 43.2%, and 16.2%, respectively. The metabolic tumor volume (MTV), total lesion glycolysis (TLG), maximum standardized uptake value, age, pathological type, extension categories, and lymph node stage were included in multivariate analyses. Multivariate analysis showed MTV (p = 0.011), TLG (p = 0.020), pathological type (p = 0.037), and extension categories (p = 0.038) were independent prognostic factors for OS. Additionally, assessment of the survival curve using the Kaplan-Meier method showed that our prognosis prediction model can effectively stratify patients with different risks factors (p < 0.001).

Conclusion: This study shows that 18F-FDG PET/CT can predict the survival of patients with primary tracheal malignant tumors. Patients with an MTV > 5.19, a TLG > 16.94 on PET/CT scans, squamous cell carcinoma, and non-E1 were more likely to have a reduced OS.

키워드

Fluorodeoxyglucose F18; Positron emission tomography computed tomography; Trachea; Prognosis; Survival

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