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Early-Phase SPECT/CT for Diagnosing Osteomyelitis: A Retrospective Pilot Study

Korean Journal of Radiology 2021년 22권 4호 p.604 ~ 611
이수진, 원경숙, 최형진, 최윤영,
소속 상세정보
이수진 ( Lee Soo-Jin ) - Hanyang University Medical Center Department of Nuclear Medicine
원경숙 ( Won Kyoung-Sook ) - Keimyung University Dongsan Hospital Department of Nuclear Medicine
최형진 ( Choi Hyung-Jin ) - Hanyang University Medical Center Department of Nuclear Medicine
최윤영 ( Choi Yun-Young ) - Hanyang University Medical Center Department of Nuclear Medicine

Abstract


Objective: The aim of this pilot study was to investigate the potential of early-phase single-photon emission computed tomography (SPECT)/computed tomography (CT) using technetium-99m methyl diphosphonate (99mTc-MDP) for diagnosing osteomyelitis (OM).

Materials and Methods: Twenty-one patients with suspected OM were enrolled retrospectively. Three-phase bone scan (TPBS), early-phase SPECT/CT (immediately after blood pool planar imaging), and delayed-phase SPECT/CT (immediately after delayed planar imaging) were performed. The final diagnoses were established through surgery or clinical follow-up for over 6 months. We compared three diagnostic criteria based on (I) TPBS alone, (II) combined TPBS and delayed-phase SPECT/CT, and (III) early-phase SPECT/CT alone.

Results: OM was diagnosed in 11 of 21 patients (nine surgically and two clinically). Of the 11 OM patients, criterion-I, criterion-II, and criterion-III were positive in six, seven, and 10 patients, respectively. Of the 10 non-OM patients, criterion-I, criterion-II, and criterion-III were negative in five, five, and seven patients, respectively. The sensitivity/specificity/accuracy of criterion-I, criterion-II, and criterion-III for diagnosing OM were 54.5%/50.0%/55.0%, 63.6%/50.0%/57.1%, and 90.9%/70.0%/87.5%, respectively.

Conclusion: This pilot study demonstrated the potential of using the early-phase SPECT/CT to diagnose OM. Based on the results, prospective studies with a larger sample size should be conducted to confirm the efficacy of early-phase SPECT/CT.

키워드

Bone and bones; Radionuclide imaging; Single photon emission computed tomography computed tomography

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