잠시만 기다려 주세요. 로딩중입니다.

Predialysis Urea Nitrogen Is a Nutritional Marker of Hemodialysis Patients

Chonnam Medical Journal 2022년 58권 2호 p.69 ~ 74
이승우, 양유미, 김혜영, 조현정, 남상원, 김선문, 권순길,
소속 상세정보
이승우 ( Lee Seung-Woo ) - Chungbuk National University Hospital Department of Internal Medicine
양유미 ( Yang Yu-Mi ) - Chungbuk National University Hospital Department of Internal Medicine
김혜영 ( Kim Hye-Young ) - Chungbuk National University Hospital Department of Internal Medicine
조현정 ( Cho Hyun-Jeong ) - Chungbuk National University Hospital Department of Internal Medicine
남상원 ( Nam Sang-Won ) - Chungbuk National University Hospital Department of Internal Medicine
김선문 ( Kim Sun-Moon ) - Chungbuk National University Hospital Department of Internal Medicine
권순길 ( Kwon Soon-Kil ) - Chungbuk National University Hospital Department of Internal Medicine

Abstract


End-stage renal disease (ESRD) patients on hemodialysis have poor nutritional status and associated problems such as inflammation and sarcopenia. Blood urea nitrogen (BUN) is an important measure of uremic toxins, and urea reduction is a marker of hemodialysis efficacy. However, a low protein diet for lower BUN could aggravate malnutrition in patients, and optimal pre-dialysis BUN is not defined. We investigated the association of pre-dialysis BUN with patients’ comorbidities and the relationship between pre-dialysis BUN and serum albumin as a nutrient marker. Among the 67 patients, the average pre- and post-dialysis BUN were 59.2 and 15.0 mg/dL, respectively, serum creatinine was 10.1 mg/dL, and the average serum albumin was 4.0 g/dL. Patients’ age was negatively correlated with serum creatinine (r=?0.277, p<0.05) and albumin (r=?0.453, p<0.001). Predialysis BUN showed a significant positive correlation with serum albumin (r=0.287, p<0.05) and creatinine (r=0.454, p<0.001). However, the predialysis BUN was not significantly related to diabetes, coronary artery disease, congestive heart failure, or cerebrovascular disease. Hemodialysis patients with high pre-dialysis BUN and high serum creatinine could be regarded as having good nutritional status. The significance of this study lies in the potential utility of pre-dialysis blood urea nitrogen as an indicator of the nutritional status of patients. Liberal protein intake might be recommended to adequately dialyzed patients.

키워드

Malnutrition; Blood Urea Nitrogen; Renal Dialysis

원문 및 링크아웃 정보

 

등재저널 정보