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해양 생물 유래 독소의 나노 기술 기반 신속 진단법 개발 동향

Trends in Rapid Detection Methods for Marine Organism-derived Toxins

한국식품위생안전성학회지 2020년 35권 4호 p.291 ~ 303
박찬영, 권소연, 문소희, 김민우, 하상도, 박종필, 박태정,
소속 상세정보
박찬영 ( Park Chan-Yeong ) - Chung-Ang University Department of Chemistry
권소연 ( Kweon So-Yeon ) - Chung-Ang University Department of Chemistry
문소희 ( Moon Sun-Hee ) - Chung-Ang University Department of Chemistry
김민우 ( Kim Min-Woo ) - Chung-Ang University Department of Chemistry
하상도 ( Ha Sang-Do ) - Chung-Ang University School of Food Science and Technology Department of Food Science and Biotechnology
박종필 ( Park Jong-Pil ) - Chung-Ang University School of Food Science and Technology Department of Food Science and Biotechnology
박태정 ( Park Tae-Jung ) - Chung-Ang University Department of Chemistry

Abstract


Marine organism-derived toxins have negative effects not only on human health but also in aquaculture, fisheries, and marine ecosystems. However, traditional analytical methods are insufficient in preventing this threat. In this paper, we reviewed new rapid methods of toxin detection, which have been improved by adopting diverse types of nanomaterials and technologies. Moreover, we herein describe the main strategies for toxin detection and their related sensing performance. Notably, to popularize and commercialize these newly developed technologies, simplifying the process of pre-treating real samples real samples is very important. As part of these efforts, numerous studies have reported pretreatment methods based on the antibody-immobilized magnetic nanoparticles, and some cases have applied nanoparticles to enhance the sensing performance by utilizing the intrinsic catalytic activity. Furthermore, some reports have introduced fluorescent nanoparticles, such as quantum dots, to represent the lower detection limits of conventional enzyme-based colorimetric methods and lateral flow assays. Some studies using electrochemical measurements based on aptamer-nanoparticle complexes have also been announced. In addition, as the response to new toxins generated by changes in the marine environment is still lacking, further research on diagnostic and detection is also greatly needed for these kinds of marine toxins and their derivatives.

키워드

Marine toxins; Rapid diagnosis; Nanomaterials; Nanobiosensor; Electrochemical detection

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