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삭시톡신과 그 유사체: 독성, 분석법, 국내외 오염도 및 관리 동향

Saxitoxin and Its Analogues: Toxicity, Analytical Method, Occurrence and Safety Management

한국식품위생안전성학회지 2020년 35권 6호 p.521 ~ 534
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Abstract


Paralytic shellfish poisoning (PSP) occurs when saxitoxin (STX), which is produced by harmfulalgae (dinoflagellates) and then accumulated in bivalve shellfish by filter-feeding, is consumed by humans. Withrecent advances in analysis technology, it has been reported that dinoflagellates also produce a variety of analoguessuch as the gonyautoxin (GTX) group and the N-sulfo-carbamoyl toxin (C toxin) group, in addition to STX. Accordingly,CODEX and the EFSA are stepping forward to manage STX and analogues as STX groups requiring safetymanagement. In Korea, the occurrence of dinoflagellates producing STX analogues has already been reported, and contaminationof analogues (GTX group, C toxin group) in live mussels has also been reported. In this study, in order to provide thebasis for systematic monitoring and safety management of STX and analogues, their physicochemical characteristics, occurrenceof dinoflagellates, toxicity and toxic equivalency factor, analytical method and occurrence were widely reviewed. Thisreview is expected to contribute to strengthening the safety management of STX and its analogues.

키워드

Paralytic shellfish poisoning; Saxitoxin; Analogues; Occurrence; Safety management

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