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신장 질환에서 생체표지자로서의 소변의 세포외 소포체의 역할

Urinary Extracellular Vesicles as Biomarkers of Kidney Disease

대한내과학회지 2021년 96권 1호 p.36 ~ 41
선인오,
소속 상세정보
선인오 ( Sun In-O ) - Presbyterian Medical Center Department of Internal Medicine Division of Nephrology

Abstract


Extracellular vesicles (EVs) are membrane-bound vesicles produced and released into the extracellular fluid by cells under physiological and stressful conditions. They play a role as intracellular communicators by carrying and delivering biomolecules, such as proteins, lipids, or nucleic acids. Urinary EVs have gained important recognition as potential diagnostic biomarkers in renal disease, as they can originate from diverse cell types, including glomerular podocytes, tubular epithelial cells, or endothelial cells. Accumulating evidence has emphasized the feasibility of using EVs as biomarkers for diagnostic, prognostic, and therapeutic purposes in several forms of renal disease, such as acute kidney injury, glomerulonephritis, and renal transplantation. In this review, we introduce recent studies that attempt to identify urinary EVs as candidate biomarkers for human kidney diseases and consider their potential implications as a therapeutic option in significant kidney diseases.

키워드

신장; 소변; 세포외 소포체
Kidney; Urine; Extracellular vesicles

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