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Assessment of Hand Motor Function in a Non-human Primate Model of Ischemic Stroke

Experimental Neurobiology 2020년 29권 4호 p.300 ~ 313
원진영, 이경식, 최치훈, 전장엽, 서진철, 김건우, 여현구, 박정형, 김유경, 진영배, 구본상, 임경섭, 이상일, 김기진, 최원석, 박성현, 김용현, 허재원, 이상래, 차상훈, 이영전,
소속 상세정보
원진영 ( Won Jin-Young ) - Korea Research Institute of Bioscience and Biotechnology National Primate Research Center
이경식 ( Yi Kyung-Sik ) - Chungbuk National University Hospital Department of Radiology
최치훈 ( Choi Chi-Hoon ) - Chungbuk National University Hospital Department of Radiology
전장엽 ( Jeon Chang-Yeop ) - Korea Research Institute of Bioscience and Biotechnology National Primate Research Center
서진철 ( Seo Jin-Cheol ) - Korea Research Institute of Bioscience and Biotechnology National Primate Research Center
김건우 ( Kim Keon-Woo ) - Korea Research Institute of Bioscience and Biotechnology National Primate Research Center
여현구 ( Yeo Hyeon-Gu ) - Korea Research Institute of Bioscience and Biotechnology National Primate Research Center
박정형 ( Park Jung-Hyung ) - Korea Research Institute of Bioscience and Biotechnology National Primate Research Center
김유경 ( Kim Yu-Gyeong ) - Korea Research Institute of Bioscience and Biotechnology National Primate Research Center
진영배 ( Jin Yeung-Bae ) - Korea Research Institute of Bioscience and Biotechnology National Primate Research Center
구본상 ( Koo Bon-Sang ) - Korea Research Institute of Bioscience and Biotechnology National Primate Research Center
임경섭 ( Lim Kyung-Seob ) - Korea Research Institute of Bioscience and Biotechnology Futuristic Animal Resource and Research Center
이상일 ( Lee Sang-Il ) - Korea Research Institute of Bioscience and Biotechnology National Primate Research Center
김기진 ( Kim Ki-Jin ) - Korea Research Institute of Bioscience and Biotechnology National Primate Research Center
최원석 ( Choi Won-Seok ) - Korea Research Institute of Bioscience and Biotechnology National Primate Research Center
박성현 ( Park Sung-Hyun ) - Korea Research Institute of Bioscience and Biotechnology National Primate Research Center
김용현 ( Kim Young-Hyun ) - Korea Research Institute of Bioscience and Biotechnology National Primate Research Center
허재원 ( Huh Jae-Won ) - Korea Research Institute of Bioscience and Biotechnology National Primate Research Center
이상래 ( Lee Sang-Rae ) - Korea Research Institute of Bioscience and Biotechnology National Primate Research Center
차상훈 ( Cha Sang-Hoon ) - Chungbuk National University Hospital Department of Radiology
이영전 ( Lee Young-Jeon ) - Korea Research Institute of Bioscience and Biotechnology National Primate Research Center

Abstract


Ischemic stroke results from arterial occlusion and can cause irreversible brain injury. A non-human primate (NHP) model of ischemic stroke was previously developed to investigate its pathophysiology and for efficacy testing of therapeutic candidates; however, fine motor impairment remains to be well-characterized. We evaluated hand motor function in a cynomolgus monkey model of ischemic stroke. Endovascular transient middle cerebral artery occlusion (MCAO) with an angiographic microcatheter induced cerebral infarction. In vivo magnetic resonance imaging mapped and measured the ischemia-induced infarct lesion. In vivo diffusion tensor imaging (DTI) of the stroke lesion to assess the neuroplastic changes and fiber tractography demonstrated three-dimensional patterns in the corticospinal tract 12 weeks after MCAO. The hand dexterity task (HDT) was used to evaluate fine motor movement of upper extremity digits. The HDT was modified for a home cage-based training system, instead of conventional chair restraint training. The lesion was localized in the middle cerebral artery territory, including the sensorimotor cortex. Maximum infarct volume was exhibited over the first week after MCAO, which progressively inhibited ischemic core expansion, manifested by enhanced functional recovery of the affected hand over 12 weeks after MCAO. The total performance time decreased with increasing success rate for both hands on the HDT. Compensatory strategies and retrieval failure improved in the chronic phase after stroke. Our findings demonstrate the recovery of fine motor skill after stroke, and outline the behavioral characteristics and features of functional disorder of NHP stroke model, providing a basis for assessing hand motor function after stroke.

키워드

Dexterity; Diffusion tensor imaging; Functional recovery; Hand function; Ischemic stroke; Magnetic resonance imaging

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