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Higher Lactate Level and Lactate-to-Pyruvate Ratio in Autism Spectrum Disorder

Experimental Neurobiology 2020년 29권 4호 p.314 ~ 322
오미애, 김순애, 유희정,
소속 상세정보
오미애 ( Oh Mi-Ae ) - Kyung Hee University Hospital Department of Psychiatry
김순애 ( Kim Soon-Ae ) - Eulji University School of Medicine Department of Pharmacology
유희정 ( Yoo Hee-Jeong ) - Seoul National University Bundang Hospital Department of Psychiatry

Abstract


Mitochondrial dysfunction is considered one of the pathophysiological mechanisms of autism spectrum disorder (ASD). However, previous studies of biomarkers associated with mitochondrial dysfunction in ASD have revealed inconsistent results. The objective of this study was to evaluate biochemical markers associated with mitochondrial dysfunction in subjects with ASD and their unaffected family members. Lactate and pyruvate levels, as well as the lactate-to-pyruvate ratio, were examined in the peripheral blood of probands with ASD (Affected Group, AG) and their unaffected family members (biological parents and unaffected siblings, Unaffected Group, UG). Lactate ≥22 mg/dl, pyruvate ≥1.4 mg/dl, and lactate-topyruvate ratio >25 were defined as abnormal. The clinical variables were compared between subjects with higher (>25) and lower (≤25) lactate-topyruvate ratios within the AG. The AG (n=59) had a significantly higher lactate and lactate-to-pyruvate ratio than the UG (n=136). The frequency of subjects with abnormally high lactate levels and lactate-to-pyruvate ratio was significantly higher in the AG (lactate 31.0% vs. 9.5%, ratio 25.9% vs. 7.3%, p<0.01). The relationship between lactate level and the repetitive behavior domain of the Autism Diagnostic Interview-Revised was statistically significant. These results suggest that biochemical markers related to mitochondrial dysfunction, especially higher lactate levels and lactateto- pyruvate ratio, might be associated with the pathophysiology of ASD. Further larger studies using unrelated individuals are needed to control for the possible effects of age and sex on chemical biomarker levels.

키워드

Autism spectrum disorder; Lactate; Pyruvate; Lactate/pyruvate ratio

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