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Susceptibility of Koi, Koi×Red Common Carp, and Red Common Carp×Koi to Koi Herpesvirus (KHV)

발생과생식 2020년 24권 4호 p.277 ~ 286
Hwang Ju-Ae, 김정은, 김형수, 박준성, 이정호,
소속 상세정보
 ( Hwang Ju-Ae ) - National Institute of Fisheries Science Inland Aquaculture Research Center
김정은 ( Kim Jung-Eun ) - National Institute of Fisheries Science Inland Aquaculture Research Center
김형수 ( Kim Hyeong-Su ) - National Institute of Fisheries Science Inland Aquaculture Research Center
박준성 ( Park Jun-Seong ) - National Institute of Fisheries Science Inland Aquaculture Research Center
이정호 ( Lee Jeong-Ho ) - National Institute of Fisheries Science Inland Aquaculture Research Center

Abstract


The disease-causing koi herpes virus (KHV), also known as cyprinid herpesvirus-3 (CyHV-3), causes mass mortality of koi and carp. Koi (Cyprinus carpio) is a host for KHV, one of 12 virus species in the Alloherpesviridae family. We examined the effects of KHV disease koi (KK), and on koi×red common carp (KR) and red common carp×koi (RK) cross, using a virus challenge test. The infected fish had clinical signs that included gill necrosis and skin lesions. The RK and KR were highly more resistant (cumulative mortality: RK; 6% and KR; 8%) to KHV infection than KK fish (cumulative mortality: 28%). KHV DNA was confirmed in the tissues of all dead fish in groups by use of polymerase chain reaction (PCR), and the presence of the KHV protein in kidney was confirmed by immunohistochemistry. Histological analysis showed severe gill lesions and fusion of the lamellae in KK fish, but less severe damage in RK fish. In immunohistochemistry analysis, the KHV protein localized in the cytoplasm of infected kidney cells of KK, but the cross groups had lower levels of KHV antigen. Our data indicate that the cross groups had increased resistance to KHV disease.

키워드

Koi; Breeding; Koi herpes virus (KHV); Gill; Kidney

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