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고지방 식이 유도 고지혈증에 대한 ChondroT의 혈액 내 지질대사에 미치는 영향

Observational Study of ChondroT's Improvement of Blood Metabolites in High-fat Diet-induced Hyperlipidemia

한방재활의학과학회지 2021년 31권 1호 p.81 ~ 93
윤찬석, 김도형, 나창수, 정지원, 김지훈, 김선길, 최지민, 김선종,
소속 상세정보
윤찬석 ( Yoon Chan-Suk ) - Dongshin University College of Korean Medicine Department of Rehabilitation Medicine of Korean Medicine
김도형 ( Kim Do-Hyeong ) - Dongshin University College of Korean Medicine Department of Rehabilitation Medicine of Korean Medicine
나창수 ( Na Chang-Su ) - Dongshin University College of Korean Medicine Department of Meridian and Acupoint
정지원 ( Jeong Ji-Won ) - Yeongam Public Health Center
김지훈 ( Kim Ji-Hoon ) - Dongshin University College of Korean Medicine Department of Rehabilitation Medicine of Korean Medicine
김선길 ( Kim Sun-Gil ) - Dongshin University College of Korean Medicine Department of Rehabilitation Medicine of Korean Medicine
최지민 ( Choi Ji-Min ) - Dongshin University College of Korean Medicine Department of Rehabilitation Medicine of Korean Medicine
김선종 ( Kim Seon-Jong ) - Dongshin University College of Korean Medicine Department of Rehabilitation Medicine of Korean Medicine

Abstract


Objectives : The objective of the study was to investigate effects of ChondroT by improvement of blood metabolites in high-fat diet (HFD)-induced hyperlipidemia rat model.

Methods : Sprague-Dawley rats were randomly assigned to intact, control, simvastatin, and CT100, CT200 and CT400 (each n=6). For observing cholesterol change, animals were first fed high fat diet for 5 weeks and then high fat diet and drugs for 3 weeks. At the end of the experiment, total cholesterol, triglyceride, high density lipoprotein-cholesterol (HDL-C) and low density lipoprotein-cholesterol (LDL-C) were analyzed by obtained blood collection. Further, amplified leptin, peroxisome proliferator activated receptor (PPAR) and adiponectin DNA were observed by reverse transcription polymerase chain reaction analysis.

Results : Observing the effect of ChondroT on the change of lipid metabolism in hyperlipidemia-induced rats, triglyceride and total cholesterol were significantly decreased in SV100 group, HDL-C was significantly increased in SV100, CT100 and CT200 groups, and LDL-C was significantly decreased in SV100, CT100, CT200 and CT400 groups, compared to the control group. Leptin level in hyperlipidemia-induced rats was significantly decreased in CT100 and CT200 groups, compared to the control group. The effect of ChondroT on adiponectin level in hyperlipidemia-induced rats was significantly increased in SV100, CT100 and CT200 groups. PPAR level in hyperlipidemia-induced rats was significantly decreased in SV100, CT200 and CT400 groups. Platelete activating factor level in hyperlipidemia-induced rats was significantly decreased in CT100 and CT200 groups.

Conclusions : Based on these results, it could be suggested that ChondroT has certain effects of improving blood metabolites in HFD-induced hyperlipidemia.

키워드

Osteoarthritis; ChondroT; High-fat diet; Hyperlipidemias

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