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Evaluation of Efficacy about Disinfectants in Biological Containment Facilities

Journal of Bacteriology and Virology 2021년 51권 1호 p.9 ~ 20
김동욱, 이경민, 최연주, 천병년, 장원종,
소속 상세정보
김동욱 ( Kim Dong-Wook ) - Konkuk University College of Medicine Department of Microbiology
이경민 ( Lee Kyung-Min ) - Konkuk University College of Medicine Department of Microbiology
최연주 ( Choi Yeon-Joo ) - Konkuk University College of Medicine Department of Microbiology
천병년 ( Chun Byung-Nyun ) - Woojungbio Company
장원종 ( Jang Won-Jong ) - Konkuk University College of Medicine Department of Microbiology

Abstract


In healthcare facilities, research facilities, and biology laboratories that handle biological agents, different types of disinfectants are used for sterilization and disinfection. In order to use disinfectants to prevent biological contamination and achieve the effective level of disinfection, accurate approaches should be considered such as selecting appropriate disinfectants and setting up effective disinfection conditions. This study performed an experiment by setting up a biologically contaminated surface in the facility such as the walls in order to examine the disinfection effects followed by the disinfectant and disinfection conditions. Geobacillus stearothermophilus, biological indicators, were used as a test organism of this study to verify the disinfection effects. Amongst what is used in many biological containment facilities, common disinfectants like DOCTOR SOLUTION, BruClean TBCTM, TexQTM, ethanol, and sterile water were used. In addition, various practiced cleaning methods like spraying and wiping were applied by combining the condition of treating with the disinfectant for each condition and the disinfection level was verified synthetically. As a result of confirming the disinfection effects by combining different combinations of disinfectants and the disinfection sessions (1~5 times), the findings suggest that disinfection was effective from the 1st disinfection wiping with 70% ethanol. For the disinfection method, the condition of more than 1 time of wiping for disinfection was effective for the inactivation of infectivity for G. stearothermophilus by displaying disinfection effects. However, it was identified that only spraying D OCTOR SOLUTION is not effective for disinfection. We also carried out an additional experiment by investigating the impact of disinfectants (hydrogen peroxide, DOCTOR SOLUTION, BruClean TBCTM, TexQTM, ethanol, and peracetic acid) on various surface materials (epoxy, stainless steel, urethane, and lab benches) in the facility. As a result of identifying the changes in the surface material followed by the disinfectants, the experiment verified that it is safe in general concentration. Therefore, the findings of this study will provide much-needed information for the selection of appropriate disinfectants and disinfection methods when decontaminating bio-containment facilities in each institution.

키워드

Sterilize; Disinfectants; Biological containment facilities

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