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Adenovirus Vectors: Excellent Tools for Vaccine Development

Immune Network 2021년 21권 1호 p.6 ~ 6
장준,
소속 상세정보
장준 ( Chang Jun ) - Ewha Womans University Graduate School of Pharmaceutical Sciences

Abstract


Adenovirus was originally used as a vector for gene therapy. In recent years, with the development of the next-generation vectors with increased safety and high immunogenicity to transgene products, its utility as a vaccine vector has continued to increase. Adenovirus-based vaccines are currently being tested not only to prevent various infectious diseases but also to be applied as cancer vaccines. In this review, I discuss the innate and adaptive aspects of the immunological characteristics of adenovirus vectors and further examine the current status of advanced adenovirus-based vaccine development. Various methods that can overcome the limitations of currently used adenoviruses as vaccine vehicles are also discussed. Through this study, I hope that vaccine development using adenovirus vectors will be expedited and more successful.

키워드

Adenovirus; Genetic vector; Adenovector; Vaccine

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