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Structure of SARS-CoV-2 Spike Glycoprotein for Therapeutic and Preventive Target

Immune Network 2021년 21권 1호 p.8 ~ 8
홍재우, 전현정, 최여옥, Taitt Afeisha S., 배서영, 이영민, 송창성, 염수청, 김수현,
소속 상세정보
홍재우 ( Hong Jae-Woo ) - Daegu Catholic University School of Medicine Department of Physiology
전현정 ( Jhun Hyun-Jhung ) - Korea Food Research Institute Technical Assistance Center
최여옥 ( Choi Yeo-Ok ) - Konkuk University Department of Biomedical Science and Technology
 ( Taitt Afeisha S. ) - Konkuk University Department of Biomedical Science and Technology
배서영 ( Bae Su-Young ) - Ministry of Food and Drug Safety Department of Bioequivalence Division for Drug Evaluation
이영민 ( Lee Young-Min ) - Inje University College of Medicine Pusan Paik Hospital Department of Medicine
송창성 ( Song Chang-Seon ) - Konkuk University College of Veterinary Medicine
염수청 ( Yeom Su-Cheong ) - Seoul National University Graduate School of International Agricultural Technology
김수현 ( Kim Soo-Hyun ) - Konkuk University Department of Biomedical Sciences and Technology

Abstract


The global crisis caused by the coronavirus disease 2019 (COVID-19) led to the most significant economic loss and human deaths after World War II. The pathogen causing this disease is a novel virus called the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). As of December 2020, there have been 80.2 million confirmed patients, and the mortality rate is known as 2.16% globally. A strategy to protect a host from SARS-CoV-2 is by suppressing intracellular viral replication or preventing viral entry. We focused on the spike glycoprotein that is responsible for the entry of SARS-CoV-2 into the host cell. Recently, the US Food and Drug Administration/EU Medicines Agency authorized a vaccine and antibody to treat COVID-19 patients by emergency use approval in the absence of long-term clinical trials. Both commercial and academic efforts to develop preventive and therapeutic agents continue all over the world. In this review, we present a perspective on current reports about the spike glycoprotein of SARS-CoV-2 as a therapeutic target.

키워드

COVID-19; SARS-CoV-2; Spike glycoprotein; Angiotensin-converting enzyme 2; Molecular targeted therapy

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