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Gastric Mucosa-associated Lymphoid Tissue Lymphoma: An Important Differential Diagnosis for a Rapidly Growing Gastric Subepithelial Tumor - A Case Report and Literature Review

김나임, 김동현, 김현수, 박선영, 조현아, 김호군,
소속 상세정보
김나임 ( Kim Nah-Ihm ) - Chonnam National University Medical School Chonnam National University Hospital Department of Pathology
김동현 ( Kim Dong-Hyun ) - Chonnam National University Medical School Chonnam National University Hospital Department of Internal Medicine
김현수 ( Kim Hyun-Soo ) - Chonnam National University Medical School Chonnam National University Hospital Department of Internal Medicine
박선영 ( Park Seon-Young ) - Chonnam National University Medical School Chonnam National University Hospital Department of Internal Medicine
조현아 ( Cho Hyun-A ) - Chonnam National University Medical School Chonnam National University Hospital Department of Internal Medicine
김호군 ( Kim Ho-Goon ) - Chonnam National University Medical School Chonnam National University Hospital Department of Surgery

Abstract


Gastric mucosa-associated lymphoid tissue (MALT) lymphoma is a low-grade lymphoma with a long median survival time because of its low proliferation rate. A 75-year-old man was referred to the hospital for hematemesis. Upper endoscopy revealed a 30-mm subepithelial tumor (SET). Abdominal CT and EUS revealed a homogeneously hypoechoic lesion arising from the second layer of the stomach, without distant metastasis. Laparoscopic wedge resection was performed. On microscopic examination, the tumor showed diffuse aggregation of small lymphoid cells with abnormal architecture. Neoplastic cells showed positive reactivity for CD20 and prominent lymphoepithelial lesions were observed. The urease breath test was also conducted, with a negative result. Our final diagnosis was Helicobacter pylori-negative MALT lymphoma (Ann Arbor classification IE2), which is a rapidly growing SET pattern. This case highlights the importance of including gastric MALT lymphoma as a differential diagnosis for rapidly growing gastric SETs.

키워드

Gastrointestinal stromal tumors; Hematemesis; Lymphoma, B-cell, Marginal zone; Stomach neoplasms

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