잠시만 기다려 주세요. 로딩중입니다.

만성 신장질환 환자에서 dual type calcium channel blocker의 사용 양상 및 결과 비교

Comparison of Usage Patterns and Outcomes by Dual Type Calcium Channel Blockers in Patients with Chronic Kidney Disease

한국임상약학회지 2020년 30권 4호 p.259 ~ 263
오미란, 안혜림, 최선, 나현오,
소속 상세정보
오미란 ( Oh Mi-Ran ) - 가톨릭대학교 서울성모병원 약제부
안혜림 ( Ahn Hye-Lim ) - Catholic University Seoul St. Mary’s Hospital Department of Pharmacy
최선 ( Choi Sun ) - Catholic Medical Center Office of Human Research Protection
나현오 ( La Hyen-O ) - Catholic University College of Pharmacy

Abstract


Background: Dual-type calcium channel blockers (CCBs), such as efonidipine and cilnidipine, are renoprotective drugs that reportedly reduce proteinuria by dilating afferent and efferent arterioles of the glomerulus. However, studies comparing the effect of dual-type CCB on proteinuria have not been conducted. Therefore, we aimed to compare the effect of dual-type CCB (efonidipine and cilnidipine) usage patterns in hypertensive patients with chronic kidney disease (CKD).
Methods: This single-center, retrospective study included 53 patients with CKD who 1) initiated efonidipine or cilnidipine treatment while on a renin-angiotensin system inhibitor and 2) had received efonidipine or cilnidipine for at least one year. We compared usage patterns between the efonidipine and cilnidipine groups during the one-year period and analyzed the following outcomes: urinary protein-to-creatinine ratio, blood pressure, and serum creatinine.

Results: The study included 25 patients in the efonidipine group and 28 patients in the cilnidipine group. In both groups, blood pressure and urinary protein-to-creatinine ratios tended to decrease; however, the change during each interval was not significant.

Conclusions: In patients with CKD who were on renin-angiotensin system inhibitor therapy, the addition of a dual-type CCB (i.e., efonidipine or cilnidipine) tended to reduce proteinuria; however, the change during each interval was not significant.

키워드

Chronic kidney disease; proteinuria; efonidipine; cilnidipine; calcium channel blocker

원문 및 링크아웃 정보

등재저널 정보