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사염화탄소로 유발된 백서 간경변의 조직학적인 변화와 cyclooxygenase-2의 발현

Relationship between Histoltgic Change and Expression of COX-2 on CCl₄-Induced Cirrhosis in the Rat

건양의대학술지 2005년 5권 1호 p.54 ~ 63
김범경, 김윤미, 이정우, 목우균, 강대영, 설혜정, 김훈,
소속 상세정보
김범경 ( Kim Bum-Kyeong ) - 건양대학교 의과대학 병리학교실
김윤미 ( Kim Yoon-Mee ) - 건양대학교 의과대학 병리학교실
이정우 ( Lee Jung-Uee ) - 건양대학교 의과대학 진단병리학교실
목우균 ( Mok Woo-Kyun ) - 건양대학교 의과대학 외과학교실
강대영 ( Kang Dae-Young ) - 충남대학교 의과대학 병리학교실
설혜정 ( Sul Hae-Joung ) - 건양대학교 의과대학 병리학교실
김훈 ( Kim Hoon ) - 건양대학교 미용학과

Abstract


COX-2 is an inducible immediate-early gene and was orginally found to be induced by various stimuli, such as mitogens and cytokines, and growth factors. Overexpression of COX-2 has been reported in various chronic inflammatory disease. The aim of this work was to examine the relationship between the expression of COX-2 and developement of the CCl4-induced cirrhosis. The rats were sacrificed at 2, 4, 6, 8, and 12 experimental weeks. The light microscopic, immunohistochemical, and TUNEL stain, along with the liver function tests were performed. The number of Kupffer cells and endothelial cell showing the expression of COX-2 and the apoptosis of hepatocytes were gradually increased during the development of cirrhosis. In the 12 weeks, the hepatocytes also showed the expression of COX-2. In serologic test, the level of total protein and albumin decreased, but the degree of aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase levels increased and the levels of increase are proportional to the experimental duration. The COX-2 expression showed the correlationship between the degree of fibrosis and the liver function test. So, it suggests that COX-2 participate in development of the liver cirrhosis and the selective inhibition of the COX-2 may prevent the progression of cirrhosis with its complication including the hepatocellular carcinoma.

키워드

Cirrhosis;COX-2;TUNEL

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