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주요 효모균과 사상형 진균의 항진균제 내성현황

Antifungal Resistance in Yeasts and Filamentous Fungi

감염과화학요법 2009년 41권 2호 p.65 ~ 71
신종희,
소속 상세정보
신종희 ( Shin Jong-Hee ) - 전남대학교 의과대학 진단검사의학교실

Abstract


The incidence of invasive fungal infection has increased worldwide along with the increasing population of high risk patients. Recently developed antifungal agents, such as second-generation triazoles and echinocandins, provide the potential to improve therapeutic options against invasive fungal infections. However, treatment of invasive fungal infections has been hampered by both intrinsic and acquired resistance to antifungal agents among many fungal pathogens. A better understanding of the clinical impact of antifungal resistance is important for selecting the proper antifungal agent in patients with systemic fungal infections. This article reviews the current situation with regard to intrinsic and acquired resistance of clinically significant yeasts and filamentous fungi against currently available antifungal agents.

키워드

Antifungal drug resistance;Azoles;Echinocandins;Amphotericin B;Filamentous fungi

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