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신증후군 출혈열

HemorrhagicFeverwithRenalSyndrome

감염과화학요법 2009년 41권 6호 p.323 ~ 332
김효열,
소속 상세정보
김효열 ( Kim Hyo-Youl ) - 연세대학교 원주의과대학 감염내과학교실

Abstract


Hemorrhagic fever with renal syndrome (HFRS) is an acute febrile illness caused by Eurasian hantaviruses and characterized by renal insufficiency, hemorrhage, thrombocytopenia, and shock. Each hantavirus is primarily associated with a single rodent host species or genus, and is transmitted to human via aerosols of rodent excreta. During the last decades, clinical features of HFRS in Korea have changed with mild degree of hypotension and very low prevalence of oliguria. Treatment of HFRS is mainly supportive. Recently, however, treatment of HFRS patients with ribavirin in China and Korea, within 7 days after the onset of fever, resulted in a reduced mortality as well as shortened course of illness. Although a commercial inactivated Hantaan virus vaccine has been on the market in Korea for more than 15 years, the effect of vaccination is not clear. Further efforts are necessary to develop safer and more effective hantavirus vaccines.

키워드

Hemorrhagic fever with renal syndrome;Hantavirus;Hantaan virus

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등재저널 정보

KCI
KoreaMed
KAMS