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Endoscopic molecular imaging in inflammatory bowel disease

Intestinal Research 2021년 19권 1호 p.33 ~ 44
함남석, 명승재,
소속 상세정보
함남석 ( Ham Nam-Seok ) - Veterans Health Service Medical Center Department of Gastroenterology
명승재 ( Myung Seung-Jae ) - University of Ulsan College of Medicine Asan Medical Center Department of Gastroenterology

Abstract


Molecular imaging is a technique for imaging the processes occurring in a living body at a molecular level in real-time, combining molecular cell biology with advanced imaging technologies using molecular probes and fluorescence. Gastrointestinal endoscopic molecular imaging shows great promise for improving the identification of neoplasms, providing characterization for patient stratification and assessing the response to molecular targeted therapy. In inflammatory bowel disease, endoscopic molecular imaging can be used to assess disease severity and predict therapeutic response and prognosis. Endoscopic molecular imaging is also able to visualize dysplasia in the presence of background inflammation. Several preclinical and clinical trials have evaluated endoscopic molecular imaging; however, this area is just beginning to evolve, and many issues have not been solved yet. In the future, it is expected that endoscopic molecular imaging will be of increasing interest among clinicians as a new technology for the identification and evaluation of colorectal neoplasm and colitis-associated cancer.

키워드

Molecular imaging; Intestinal diseases; Inflammatory bowel disease; Colitis; Neoplasm

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