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The role of platelet to lymphocyte ratio and neutrophil to lymphocyte ratio in ulcerative colitis

Intestinal Research 2021년 19권 1호 p.62 ~ 70
정유진, 전성란, 김현건, 문정락, 이태희, 장재영, 조준형, 박준석, 박희수, 이기훈, 김진오, 이준성,
소속 상세정보
정유진 ( Jeong Yu-Jin ) - Soonchunhyang University College of Medicine Institute for Digestive Research Digestive Disease Center
전성란 ( Jeon Seong-Ran ) - Soonchunhyang University College of Medicine Institute for Digestive Research Digestive Disease Center
김현건 ( Kim Hyun-Gun ) - Soonchunhyang University College of Medicine Institute for Digestive Research Digestive Disease Center
문정락 ( Moon Jung-Rock ) - Soonchunhyang University College of Medicine Institute for Digestive Research Digestive Disease Center
이태희 ( Lee Tae-Hee ) - Soonchunhyang University College of Medicine Institute for Digestive Research Digestive Disease Center
장재영 ( Jang Jae-Young ) - Soonchunhyang University College of Medicine Institute for Digestive Research Digestive Disease Center
조준형 ( Cho Jun-Hyung ) - Soonchunhyang University College of Medicine Institute for Digestive Research Digestive Disease Center
박준석 ( Park Jun-Seok ) - Soonchunhyang University College of Medicine Institute for Digestive Research Digestive Disease Center
박희수 ( Park Hee-Su ) - Soonchunhyang University College of Medicine Institute for Digestive Research Digestive Disease Center
이기훈 ( Lee Ki-Hun ) - Soonchunhyang University College of Medicine Institute for Digestive Research Digestive Disease Center
김진오 ( Kim Jin-Oh ) - Soonchunhyang University College of Medicine Institute for Digestive Research Digestive Disease Center
이준성 ( Lee Joon-Seong ) - Soonchunhyang University College of Medicine Institute for Digestive Research Digestive Disease Center

Abstract


Background/Aims: Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) can serve as biomarkers for diagnosing and assessing disease activity in ulcerative colitis (UC). We investigated their clinical significance in UC.

Methods: We analyzed 48 patients with UC who underwent measurement of fecal calprotectin (FC) and endoscopy and 96 age- and sex-matched healthy controls. NLR and PLR were compared between the patients and healthy controls. The endoscopic activity was divided into 2 groups: group 1 (mild to moderate inflammation) and group 2 (severe inflammation) according to the Mayo endoscopic subscore in UC.

Results: To diagnose UC, the optimal cutoff of NLR and PLR was 2.26 (sensitivity 54.2%; specificity 90.6%; positive likelihood ratio 5.778, 95% confidence interval [CI] 2.944?11.339; area under the curve [AUC] 0.774, 95% CI, 0.690?0.859) and 179.8 (sensitivity 35.4%; specificity 90.6%; positive likelihood ratio 3.778, 95% CI 1.821?7.838; AUC 0.654, 95% CI 0.556?0.753), respectively. The optimal cutoff to differentiate group 1 and group 2 was 3.44, 175.9, and 453 μg/g for NLR, PLR, and FC, respectively (sensitivity, 63.6% vs. 90.9% vs. 81.8%; specificity, 81.1% vs. 78.4% vs. 73.0%; positive likelihood ratio, 3.364 vs. 4.205 vs. 3.027; AUC, 0.714 vs. 0.897 vs. 0.813). PLR had the highest AUC and positive likelihood ratio.

Conclusions: NLR and PLR help differentiate patients with UC from healthy controls. NLR, PLR, and FC indicate endoscopic activity and may reflect intestinal mucosal conditions.

키워드

Colitis, ulcerative; Neutrophil to lymphocyte ratio; Platelet to lymphocyte ratio; Fecal calprotectin

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