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Comparison of Biomechanical Properties of Dura Mater Substitutes and Cranial Human Dura Mater : An In Vitro Study

Journal of Korean Neurosurgical Society 2019년 62권 6호 p.635 ~ 642
Kizmazoglu Ceren, Aydin Hasan Emre, Kaya Ismail, Atar Murat, Husemoglu Bugra, Kalemci Orhan, Sozer Gulden, Havitcioglu Hasan,
소속 상세정보
 ( Kizmazoglu Ceren ) - Dokuz Eylul University School of Medicine Department of Neurosurgery
 ( Aydin Hasan Emre ) - Kutahya Health Science University Evliya Celebi Training and Research Hospital Department of Neurosurgery
 ( Kaya Ismail ) - Kutahya Health Science University Evliya Celebi Training and Research Hospital Department of Neurosurgery
 ( Atar Murat ) - Sultan Abdulhamid Han Training and Research Hospital Department of Neurosurgery
 ( Husemoglu Bugra ) - Dokuz Eylul University School of Medicine Health Science Institute Department of Biomechanics
 ( Kalemci Orhan ) - Dokuz Eylul University School of Medicine Department of Neurosurgery
 ( Sozer Gulden ) - Forensic Medicine Institution Department of Pathology
 ( Havitcioglu Hasan ) - Dokuz Eylul University School of Medicine Health Science Institute Department of Biomechanics

Abstract


Objective : The aim of this study was to investigate the biomechanical differences between human dura mater and dura mater substitutes to optimize biomimetic materials.

Methods : Four groups were investigated. Group I used cranial dura mater (n=10), group II used Gore-Tex® Expanded Cardiovascular Patch (W.L. Gore & Associates Inc., Flagstaff, AZ, USA) (n=6), group III used Durepair® (Medtronic Inc., Goleta, CA, USA) (n=6), and group IV used Tutopatch® (Tutogen Medical GmbH, Neunkirchen am Brand, Germany) (n=6). We used an axial compression machine to measure maximum tensile strength.

Results : The mean tensile strengths were 7.01±0.77 MPa for group I, 22.03±0.60 MPa for group II, 19.59±0.65 MPa for group III, and 3.51±0.63 MPa for group IV. The materials in groups II and III were stronger than those in group I. However, the materials in group IV were weaker than those in group I.

Conclusion : An important dura mater graft property is biomechanical similarity to cranial human dura mater. This biomechanical study contributed to the future development of artificial dura mater substitutes with biomechanical properties similar to those of human dura mater.

키워드

Mechanics; Collagen; Dura mater; Pericardium; Polytetrafluoroethylene

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