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Upper Cervical Subluxation and Cervicomedullary Junction Compression in Patients with Rheumatoid Arthritis

Journal of Korean Neurosurgical Society 2019년 62권 6호 p.661 ~ 670
정재우, 백광흠, 이형중, 전형준, 류제일, 한명훈,
소속 상세정보
정재우 ( Chung Jae-Woo ) - Hanyang University Medical Center Department of Neurosurgery
백광흠 ( Bak Koang-Hum ) - Hanyang University Medical Center Department of Neurosurgery
이형중 ( Yi Hyeong-Joong ) - Hanyang University Medical Center Department of Neurosurgery
전형준 ( Chun Hyoung-Joon ) - Hanyang University Medical Center Department of Neurosurgery
류제일 ( Ryu Je-Il ) - Hanyang University Medical Center Department of Neurosurgery
한명훈 ( Han Myung-Hoon ) - Hanyang University Medical Center Department of Neurosurgery

Abstract


Objective: Rheumatoid arthritis (RA) is known to involve the cervical spine up to 86%. It often causes cervical instability like atlantoaxial subluxation (AAS), subaxial subluxation, and vertical subluxation (VS). In order to find the relation between RA and cord compression, we will evaluate the characteristics and risk factors of basilar invagination (BI) and cervicomedullary junction (CMJ) compression.

Methods: From January 2007 to May 2015, 12667 patients administrated to Hanyang University Medical Center. Four thousand three hundred eighty-six patients took cervical X-ray and 250 patients took cervical computed tomography or magnetic resonance imaging. Radiologic parameters, medication records were obtained from 242 patients. Multivariate logistic regression analysis was performed with correlation of CMJ compression, basin-dental interval (BDI), basin-posterior axial line interval (BAI), pannus formation, BI, and AAS.

Results: In the point of CMJ compression, atlantodental interval (ADI), posterior-atlantodental interval, BAI, AAS, and BI are relatively highly correlated. Patients with BI have 82 times strong possibility of radiologic confirmed CMJ compression, while AAS has 6-fold and pannus formation has the 3-fold possibility. Compared to the low incidence of BI, AAS and pannus formation have more proportion in CMJ compression. Furthermore, wrist joint erosion was correlated with VS and AAS.

Conclusion: BI has a very strong possibility of CMJ compression, while AAS and pannus formation have a high proportion in CMJ compression. Hence bilateral wrist joint erosion can be used as an indicator for the timing of screening test for cervical involvement. We suggest the early recommendation of cervical spine examination for the diagnosis of cervical involvement in order to prevent morbidity and mortality.

키워드

Rheumatoid arthritis; Brainstem compression

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