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The Relationship between Parkinson’s Disease and Acute Myocardial Infarction in Korea : A Nationwide Longitudinal Cohort Study

Journal of Korean Neurosurgical Society 2022년 65권 4호 p.507 ~ 513
신승훈, 홍제범, 김하경, 김지민, 한인보, 손세일,
소속 상세정보
신승훈 ( Sheen Seung-Hun ) - CHA University CHA Bundang Medical Center Department of Neurosurgery
홍제범 ( Hong Je-Beom ) - Sungkyunkwan University School of Medicine Kangbuk Samsung Hospital Department of Neurosurgery
김하경 ( Kim Ha-Kyung ) - Seoul National University Graduate School of Public Health Department of Public Health
김지민 ( Kim Ji-Min ) - Cornell University
한인보 ( Han In-Bo ) - CHA University CHA Bundang Medical Center Department of Neurosurgery
손세일 ( Sohn Se-Il ) - CHA University CHA Bundang Medical Center Department of Neurosurgery

Abstract


Objective: The goal of the following statewide age and gender-coordinated cohort study in Korea is to find out if there is a link between acute myocardial infarction (AMI) and Parkinson’s disease (PD).

Methods: Utilizing the National Health Insurance Sharing Service cohort, patient data were collected. Six thousand four hundred seventy-five individuals with PD were distinguished by utilizing the International Classification of Diseases 10 code G20 and have enrolled in the PD group. The number of participants decreased to 5259 after excluding 1039 patients who were hospitalized less than one time or who visited an outpatient clinic less than twice. Then, 26295 individuals were selected as part of the control group after case control matching was conducted through 1 : 5 age- and gender-coordinated matching. The Cox proportional hazard regression analysis and Kaplan-Meier method were utilized to analyze the likelihood of AMI in PD.

Results: After controlling for age and gender, the hazard ratio of AMI in the PD group was 3.603 (95% confidence interval [CI], 2.837-4.577). After that, the following hazard ratio of AMI in the PD group was modified against for co-morbid medical disorders, resulting in 3.551 (95% CI, 2.795-4.511). According to a subgroup analysis, in males and females aged <65 and aged ≥65 and in the non-diabetes and diabetes, hypertension and non-hypertension, dyslipidemia and non-dyslipidemia subgroups, the AMI incidence rates were dramatically higher in the PD group compared to that of the control.

Conclusion: Individuals with PD have a greater chance of AMI, according to this cross-national study.

키워드

Parkinson’s disease; Population; Myocardial infarction; Epidemiology

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