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Neuroprotective effects of ethanolic extract from dry Rhodiola rosea L. rhizomes

Food Science and Biotechnology 2021년 30권 2호 p.287 ~ 297
김관중, 정영성, 유동민, 이승현, 이금산, 권강범, 김대옥,
소속 상세정보
김관중 ( Kim Kwan-Joong ) - Kyung Hee University Department of Food Science and Biotechnology
정영성 ( Jung Young-Sung ) - Korea Food Research Institute
유동민 ( You Dong-Min ) - SK Bioland Co. Ltd.
이승현 ( Lee Seung-Hyun ) - SK Bioland Co. Ltd.
이금산 ( Lee Guem-San ) - Wonkwang University College of Korean Medicine Department of Herbology
권강범 ( Kwon Kang-Beom ) - Wonkwang University College of Korean Medicine Department of Korean Physiology
김대옥 ( Kim Dae-Ok ) - Kyung Hee University Department of Food Science and Biotechnology

Abstract


Rhodiola rosea L. rhizome has been used as a traditional medicine to treat fatigue, depression, and cognitive dysfunction. We aimed to authenticate R. rosea L. rhizome using the DNA barcoding technique and to quantify its main compounds, total phenolics, total flavonoids, and antioxidant capacity, and then to investigate their neuroprotective effects. The sequences of internal transcribed spacer and trnH-psbA of R. rosea L. rhizomes showed a 99% identity with those of NCBI GenBank database according to BLAST searches. Analysis using reversed-phase HPLC revealed five main compounds in R. rosea L. rhizome. Rhodiola rosea L. rhizome and two bioactive compounds, salidroside and tyrosol, showed free radical scavenging activity. Rhodiola rosea L. rhizome and its identified compounds protected neuronal PC-12 cells against oxidative stress and showed moderate acetylcholinesterase inhibition. Taken together, these results suggest that R. rosea L. rhizomes with bioactives can be used as a functional ingredient with potential for neuroprotection.

키워드

Acetylcholinesterase; DNA barcoding; Oxidative stress; Salidroside; Tyrosol

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